Evidence map›Paper›PMID 40094785›Full record

ReviewJournal of clinical medicine2025

Fetoscopic Myelomeningocele (MMC) Repair: Evolution of the Technique and a Call for Standardization.

Stephanie M Cruz, Sophia Hameedi, Lourenco Sbragia, Oluseyi Ogunleye, Karen Diefenbach, Albert M Isaacs, Adolfo Etchegaray, Oluyinka O Olutoye

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephanie M CruzThe Fetal Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0002-1815-6236
Sophia HameediDepartment of Pediatric Surgery, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Lourenco SbragiaCenter for Regenerative Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Oluseyi OgunleyeThe Fetal Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Karen DiefenbachThe Fetal Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Albert M IsaacsThe Fetal Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Adolfo EtchegarayThe Fetal Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0002-6241-0596
Oluyinka O OlutoyeThe Fetal Center, Nationwide Children's Hospital, Columbus, OH 43205, USA.ORCID 0000-0003-1619-3970

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fetal surgery has made significant strides over the past 40 years, facilitated by advances in technology and imaging modalities enabling the diagnosis and treatment of congenital anomalies in utero. The Management of Myelomeningocele Study (MOMS), a multicenter randomized controlled trial, established open fetal myelomeningocele (MMC) repair as the gold standard for improving neurological outcomes compared to postnatal repair. However, this approach is associated with increased maternal complications and preterm birth due to hysterotomy, prompting the exploration of minimally invasive alternatives. Due to the lack of an existing randomized control trial with fetoscopic MMC repair and variations in technique (percutaneous versus laparotomy/transuterine access, different trocar configurations, closure methods, and patch applications) among different fetal centers, more studies are needed to optimize this approach as an alternative to the standard of care. This paper proposes to assess the basics tenets of open fetal MMC repair and to establish guiding principles for a fetoscopic approach that could prove to be equivalent or superior to open fetal MMC repair in maternal and fetal outcomes and lead to clinical implementation.

Indexed as

fetal repairfetoscopyMMCmyelomeningocelespina bifida

Identifiers

PMID40094785
PMCPMC11900223

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.