ArticleJournal of the American Chemical Society2025
A Catalysis-Driven Dual Molecular Motor.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Autonomous migration of a phosphate group along glycerol and inositol scaffolds driven by a phosphodiester reaction cycle.Nature chemistry · 2026Article
- Chiral catalysis-driven rotary molecular motors.Nature chemistry · 2026Article
- Enzyme-Free Phosphorylation with Kinetic Gating in a De Novo Coiled-Coil System.Journal of the American Chemical Society · 2026Article
- Recent Advancements in Information Ratchet Design.Molecules (Basel, Switzerland) · 2026Review
- Stimuli-Responsive Chemical Systems That Mimic Biological Dynamics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Controlling molecular machinesChemical science · 2025Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report on a head-to-tail dual molecular motor consisting of two (identical) motor units whose pyrrole-2-carboxylic rings are turned in contra-rotary (i.e., disrotatory) fashion about a common phenyl-2,5-dicarboxylic acid stator. The motors directionally rotate via information ratchet mechanisms, in which the hydration of a carbodiimide (fuel) to form urea (waste) is catalyzed through the chemomechanical cycle of a motor unit, resulting in directional rotation about a biaryl C-N bond. The head-to-tail arrangement of the motor units produces coaxial contra-rotation of the end groups while the central phenyl ring of the axis remains dynamically unbiased. The electron-rich nature of the phenyl stator contributes to rotary catalysis by the dual-motor (and therefore motor rotation itself) being ∼7× faster than the parent 1-phenylpyrrole-2,2-dicarboxylic acid single-motor when operated under identical conditions, and 90× faster than the single-motor operated using the originally reported reaction conditions. Under batch-fueled operation (i.e., all of the fuel present at the start of motor operation), the dual-motor rotates at an initial rate of 0.43 rotations per minute (rpm). Chemostating the fuel concentration by syringe pump addition produced sustained repetitive contra-rotation at a rate of 0.24 rpm for a period of 100 min. The demonstration of chemically fueled continuous contra-rotation on a time scale of 2-4 min per rotation significantly advances the chemistry and mechanics of artificial catalysis-driven molecular machinery.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.