GuidelineJournal of the American Heart Association2025
Blood Culture-Negative Endocarditis: A Scientific Statement From the American Heart Association:
Guideline in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- A rare presentation of nonbacterial thrombotic endocarditis.Journal of vascular surgery cases and innovative techniques · 2026Article
- A silent culprit: Prosthetic valve endocarditis due toRadiology case reports · 2026Article
- Diagnostic Yield and Incremental Value of 16S rRNA Gene PCR and Sequencing on Excised Heart-Valve Tissue in Infective Endocarditis: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2026Review
- Mural Right-Sided Infective Endocarditis in Adults: A Systematic Review.JACC. Advances · 2026Article
- When Stroke Speaks First: A Case Report on the Hidden Face of Streptococcus mitis Endocarditis.Cureus · 2026Article
- Metagenomic next-generation sequencing in blood culture-negative endocarditis: a structured review with illustrative pooled estimates.Infection · 2026Review
- Impact of the COVID-19 Pandemic on Presentation, Microbiology, and Outcomes of Infective Endocarditis: A Romanian Retrospective Cohort Study.Antibiotics (Basel, Switzerland) · 2026Article
- Whipple's endocarditis and biologic response modifiers: a case-based review of an intricate host-pathogen interaction.Infection · 2026Review
- Mitral valve calcific embolization leading to myocardial infarction in a patient with end-stage renal disease.Oxford medical case reports · 2026Article
- Probable Bartonella clarridgeiae Prosthetic Valve Endocarditis and Aortic Root Abscess, Australia, 2020.Emerging infectious diseases · 2026Article
- Microbial Cell-Free DNA Sequencing as a Novel Diagnostic for Culture-Negative Gemella haemolysans Endocarditis.JACC. Case reports · 2026Article
- IS-Pro-based pathogen detection in explanted heart valves of suspected endocarditis patients.Microbiology spectrum · 2026Article
- Predictors of In-Hospital Mortality From Infective Endocarditis in a Resource-Limited, War-Affected Tertiary Center.Reviews in cardiovascular medicine · 2026Article
- Blood Culture-Negative Legionella TAVR Endocarditis.JACC. Case reports · 2026Article
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- Mitral Valve Endocarditis Due to Whipple Disease: A Rare Cause of Subacute Endocarditis.JACC. Case reports · 2026Article
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- Elevated NT-proBNP in the Setting of Ongoing Chest Infection Leading to Incidental Diagnosis of Infective Endocarditis-A Case Report.Case reports in cardiology · 2026Article
- Comparative diagnostic performance of plasma microbial cell-free DNA sequencing versus amplicon-based blood next-generation sequencing in suspected bloodstream or endovascular infection: a single-center study.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood culture-negative endocarditis has been associated with worse outcomes when compared with blood culture-positive endocarditis, because pathogen-directed antimicrobial therapy and other management aspects have been difficult to achieve. Novel diagnostic tools, however, have changed the landscape of this syndrome and will likely improve patient outcomes. This American Heart Association scientific statement highlights these advances. The writing group, which represents a multidisciplinary team, provides an update on blood culture-negative endocarditis. Clinical scenarios representative of real-world experiences are included to assist frontline clinicians in the diagnosis and management of this syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.