Evidence map›Paper›PMID 40094145›Full record

ArticleInternational journal of pharmaceutics: X2025

Non-destructive quantification of low colchicine concentrations in commercially available tablets using transmission raman spectroscopy with partial least squares.

Ningzi Guo, Sijing Niu, Ying Geng, Guangzhi Shan, Ningyi Wei, Hua Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ningzi GuoNational Institutes for Food and Drug Control, No. 31, Huatuo Road, Beijing 102629, China.
Sijing NiuNational Institutes for Food and Drug Control, No. 31, Huatuo Road, Beijing 102629, China.
Ying GengNational Institutes for Food and Drug Control, No. 31, Huatuo Road, Beijing 102629, China.
Guangzhi ShanInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Tian Tan Xi Li, Beijing 100050, China.
Ningyi WeiNational Institutes for Food and Drug Control, No. 31, Huatuo Road, Beijing 102629, China.
Hua ChenNational Institutes for Food and Drug Control, No. 31, Huatuo Road, Beijing 102629, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The narrow therapeutic index and significant toxicity of colchicine (COL) underscore the importance of content uniformity of dosage units to ensure drug safety and efficacy. In this study, transmission Raman spectroscopy (TRS) technology combined with partial least squares (PLS) regression was used for the non-destructive determination of low concentration levels of COL in commercial tablets (0.83 %

Indexed as

Chemometric analysisColchicineCommercial tabletsContent uniformityPartial least squaresTransmission Raman spectroscopy

Identifiers

PMID40094145
PMCPMC11910358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.