ArticleJB & JS open access
Descriptive Epidemiology of Venous Thromboembolism in Pediatric Orthopedic Patients: A National, Multicenter Study.
Article in JB & JS open access. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Consensus regarding which children within orthopedics would benefit from venous thromboembolism (VTE) prophylaxis is lacking. Our objective was to explore the incidence and epidemiology of VTE within pediatric orthopedics through a multicenter review across the United States. Methods: Encompassing 13 pediatric centers nationwide, VTE incidence rates with 95% confidence interval (CIs) were determined for all pediatric nonorthopedic patients (PNOPs) in general (age 0-18 years) and compared with pediatric orthopedic patients (POPs) from both inpatient and outpatient settings between 2014 and 2017. Demographics, risk factors, presence of prophylaxis, treatment, and outcomes for POP VTEs were analyzed using descriptive statistics. Results: Of 10,040,937 total unique patients, the overall 4-year VTE incidence for PNOPs was 2.1 per 10,000 patients (CI 2.01-2.19). Of 141,545 POPs, the VTE incidence was 8.0 per 10,000 patients (CI 6.61-9.63). The weighted median age for POP VTEs was higher than that for PNOP VTEs (11.5 vs. 8.0 years, p = 0.001). Of the 113 POP VTEs, 97 eligible patients (median age 13.3 years, 56% male) with complete data were further analyzed: 85% (82/97) underwent orthopedic surgery for trauma, infection, or an elective procedure. Orthopedic procedures (49%), bacteremia (46%), central venous catheters (38%), and trauma (28%) were the most common risk factors associated with VTE development, mostly occurring during the initial hospitalization (65%). Thirty-four percent (33/97) of VTE cases had received prophylaxis, predominantly pharmacological (26/33, 79%), administered postoperatively. Ninety-seven percent (94/97) of POP VTEs were treated with anticoagulation, most frequently low-molecular-weight heparin (79%). Twenty-two percent of POP VTEs experienced complications, 2 (2%) of which were deaths, with one having received postoperative VTE prophylaxis. Conclusions: Although relatively rare, the true incidence of pediatric orthopedic-related VTE may be greater than that of nonpediatric orthopedic VTE, with child mortality occurring in a small minority of cases. In children diagnosed with VTE, one third had received VTE prophylaxis. Identifying at-risk children undergoing orthopedic surgery and establishing best practice safety protocols for VTE prevention are critical to prevent associated morbidity and mortality. Level of Evidence: Level III-Retrospective comparative study. See Instructions for Authors for a complete description of levels of evidence.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.