ArticleFrontiers in oncology2025
Case Report: A rare case of early esophageal basaloid squamous cell carcinoma with ductal differentiation.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Early esophageal basaloid squamous cell carcinoma (EBSCC) with ductal differentiation is a rare variant of esophageal cancer (EC), for which the clinical behavior, endoscopic features and diagnostic criteria are not fully elucidated. Case presentation: An 81-year-old female presented to our hospital with a year of eating obstruction sensation. A rough, superficial-elevated and circumferential 1/2 esophageal lesion on the upper esophagus was found by the white light endoscopy (WLE). The uplift and swelling caused by subepithelial lesions suggest that this lesion may infiltrate into the submucosa. Under the narrow band imaging magnifying endoscopy (NBI-ME), papillary-like structures were visible in the lesion, and the loop capillaries classified as intraepithelial papillary capillary loop (IPCL) of type B1 were observed. Furthermore, a fine network pattern of microvascular similar to the surface glandular structure in early differentiated gastric cancer can be seen in the middle of type B1, indicating that the presence of special glandular tubular-like components. Microscopically, the tumor was a poorly differentiated EBSCC with a glandular structure. In addition, the tubular structures transitional with the surface squamous cell carcinoma. Immunohistochemical results showed that the bilayer-tubular structures exhibited bidirectional differentiation towards the outer basal epithelium and the inner columnar epithelium. The double-layer epithelium cells of the tumorous tubules expressed CK7, and the outer cells expressed p40, CK5/6. Conclusion: Early EBSCC with ductal differentiation has unique endoscopic, histological and immunophenotypic characteristics. Understanding of the endoscopic and pathological features of the early EBSCC with ductal differentiation is crucial for early detection, accurate diagnosis, timely treatment, and prevention of misdiagnosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.