Evidence map›Paper›PMID 40093983›Full record

ReviewTherapeutic advances in medical oncology2025

The dual role of gut microbiota in pancreatic cancer: new insights into onset and treatment.

Huijuan Cheng, Hongkai Guo, Chengming Wen, Guodong Sun, Futian Tang, Yumin Li

Abstract readReview
In one paragraph

Review in Therapeutic advances in medical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huijuan ChengSchool of Life Sciences, Lanzhou University, Lanzhou, Gansu, P.R. China.ORCID https://orcid.org/0000-0003-3929-9225
Hongkai GuoThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, P.R. China.ORCID https://orcid.org/0009-0009-7624-8209
Chengming WenThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, P.R. China.ORCID https://orcid.org/0009-0002-9069-954X
Guodong SunThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, P.R. China.ORCID https://orcid.org/0000-0003-1872-0068
Futian TangGansu Provincial Key Laboratory of Environmental Oncology, Lanzhou University Second Hospital, Lanzhou, Gansu, P.R. China.
Yumin LiGansu Provincial Key Laboratory of Environmental Oncology, Lanzhou University Second Hospital, No. 82, Cuiyingmen, Chengguan, Lanzhou, Gansu 730000, P.R. China.ORCID https://orcid.org/0000-0002-9267-1412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer ranks among the most lethal digestive malignancies, exhibiting a steadily increasing incidence and mortality worldwide. Despite significant advances in cancer research, the 5-year survival rate remains below 10%, predominantly due to delayed diagnosis and limited therapeutic options. Concurrently, the gut microbiota-an integral component of host physiology-has emerged as a crucial player in the pathogenesis of pancreatic cancer. Mounting evidence indicates that alterations in gut microbial composition and function may influence tumor initiation, progression, and response to therapy. This review provides an in-depth examination of the intricate interplay between the gut microbiome and pancreatic cancer, highlighting potential diagnostic biomarkers and exploring microbiome-targeted therapeutic strategies to improve patient outcomes.

Indexed as

cancer prognosisgut microbiotaimmunotherapypancreatic cancertumor microenvironment

Identifiers

PMID40093983
PMCPMC11909682

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.