Evidence map›Paper›PMID 40093909›Full record

ArticleTheranostics2025

PBRM1 deficiency enhances PD1 immunotherapeutic sensitivity via chromosomal accessibility in colorectal cancer.

Rui Li, Jie He, Chaoqun Liu, Zesheng Jiang, Jiasheng Qin, Kun Liang, Zhuocheng Ji, Liang Zhao

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rui LiDepartment of Pathology, Shunde Hospital of Southern Medical University, Foshan, China.
Jie HeDepartment of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, Basic Medical College, Southern Medical University, Guangzhou, China.
Chaoqun LiuDepartment of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, Basic Medical College, Southern Medical University, Guangzhou, China.
Zesheng JiangGeneral Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Jiasheng QinGeneral Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Kun LiangDepartment of Pathology & Guangdong Province Key Laboratory of Molecular Tumor Pathology, Basic Medical College, Southern Medical University, Guangzhou, China.
Zhuocheng JiGeneral Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Liang ZhaoDepartment of Pathology, Shunde Hospital of Southern Medical University, Foshan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Colorectal NeoplasmsDNA-Binding ProteinsDrug Resistance, NeoplasmImmune Checkpoint InhibitorsTranscription FactorsAnimalsCell LineExome SequencingFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateLymphocytes, Tumor-InfiltratingMiceMice, Inbred BALB CMice, KnockoutDNA-Binding ProteinsImmune Checkpoint InhibitorsNF-kappa BPBRM1 protein, humanPbrm1 protein, mouseProgrammed Cell Death 1 ReceptorTranscription FactorsChromosome accessibilityColorectal cancerExosomePBRM1PD1 immunotherapeutic

Identifiers

PMID40093909
PMCPMC11905143

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.