Evidence map›Paper›PMID 40093902›Full record

SynthesisTheranostics2025

Time for action: actinium-225 PSMA-targeted alpha therapy for metastatic prostate cancer - a systematic review and meta-analysis.

Gaia Ninatti, Pietro Scilipoti, Cristiano Pini, Francesco Barletta, Mattia Longoni, Fabrizia Gelardi, Martina Sollini, Giorgio Gandaglia, Mike Sathekge, Francesco Montorsi and 2 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Evaluation of the safety and efficacy ofEuropean radiology experimental · 2026
    Trial
  4. Review
  5. Review
  6. Article
  7. PET-based risk stratification for adverse events under [European journal of nuclear medicine and molecular imaging · 2026
    Article
  8. Article
  9. Refining the clinical utility of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gaia NinattiNuclear Medicine Department, IRCCS San Raffaele Hospital, Milan, Italy.
Pietro ScilipotiUnit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, IRCCS San Raffaele Scientific Institute, Italy.
Cristiano PiniNuclear Medicine Department, IRCCS San Raffaele Hospital, Milan, Italy.
Francesco BarlettaUnit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, IRCCS San Raffaele Scientific Institute, Italy.
Mattia LongoniUnit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, IRCCS San Raffaele Scientific Institute, Italy.
Fabrizia GelardiNuclear Medicine Department, IRCCS San Raffaele Hospital, Milan, Italy.
Martina SolliniNuclear Medicine Department, IRCCS San Raffaele Hospital, Milan, Italy.
Giorgio GandagliaUnit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, IRCCS San Raffaele Scientific Institute, Italy.
Mike SathekgeDepartment of Nuclear Medicine, University of Pretoria & Steve Biko Academic Hospital, Pretoria, South Africa.
Francesco MontorsiUnit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, IRCCS San Raffaele Scientific Institute, Italy.
Arturo ChitiNuclear Medicine Department, IRCCS San Raffaele Hospital, Milan, Italy.
Alberto BrigantiUnit of Urology/Division of Oncology, Gianfranco Soldera Prostate Cancer Lab, IRCCS San Raffaele Scientific Institute, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ActiniumAlpha ParticlesAntigens, SurfaceGlutamate Carboxypeptidase IIProstatic Neoplasms, Castration-ResistantRadiopharmaceuticalsHumansMaleNeoplasm MetastasisProstate-Specific AntigenProstatic NeoplasmsTreatment OutcomeActiniumActinium-225Antigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IIProstate-Specific AntigenRadiopharmaceuticalsmCRPCprostate cancerPSA responsePSMAtargeted alpha therapy

Identifiers

PMID40093902
PMCPMC11905128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.