Evidence map›Paper›PMID 40093900›Full record

ArticleTheranostics2025

SPEAR: CRISPR-mediated ultrasensitive, specific and rapid one-pot detection strategy for cancer-related SNPs.

Linlin Bai, Yanan Pang, Ting Wang, Shengzhou Wang, Kaiming Guo, Tian Xuan, Ziqin Zhang, Dianwei Liu, Feng Qian, Yan Zheng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Linlin BaiCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Human Phenome Institute, State Key Laboratory of Genetic Engineering, School of Life Sciences, School of Pharmacy, Fudan University, Shanghai 200438, China.
Yanan PangDepartment of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital; National Key Laboratory of Immunity and Inflammation, Naval Medical University, Shanghai 200433, China.
Ting WangDepartment of Hematology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China.
Shengzhou WangCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Human Phenome Institute, State Key Laboratory of Genetic Engineering, School of Life Sciences, School of Pharmacy, Fudan University, Shanghai 200438, China.
Kaiming GuoCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Human Phenome Institute, State Key Laboratory of Genetic Engineering, School of Life Sciences, School of Pharmacy, Fudan University, Shanghai 200438, China.
Tian XuanCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Human Phenome Institute, State Key Laboratory of Genetic Engineering, School of Life Sciences, School of Pharmacy, Fudan University, Shanghai 200438, China.
Ziqin ZhangCollege of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.
Dianwei LiuCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Human Phenome Institute, State Key Laboratory of Genetic Engineering, School of Life Sciences, School of Pharmacy, Fudan University, Shanghai 200438, China.
Feng QianCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Human Phenome Institute, State Key Laboratory of Genetic Engineering, School of Life Sciences, School of Pharmacy, Fudan University, Shanghai 200438, China.
Yan ZhengCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Human Phenome Institute, State Key Laboratory of Genetic Engineering, School of Life Sciences, School of Pharmacy, Fudan University, Shanghai 200438, China.
Gang JinDepartment of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China.
Rui WangCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Human Phenome Institute, State Key Laboratory of Genetic Engineering, School of Life Sciences, School of Pharmacy, Fudan University, Shanghai 200438, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CRISPR-Cas SystemsNeoplasmsNucleic Acid Amplification TechniquesPolymorphism, Single NucleotideHumansMolecular Diagnostic TechniquesPoint MutationSensitivity and Specificitycancer screeningCRISPRNEARone-potSNP detection

Identifiers

PMID40093900
PMCPMC11905141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.