ArticleFrontiers in nutrition2025
Dietary protein requirements of older adults with sarcopenia determined by the indicator amino acid oxidation technology.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Beyond the bare minimum: the case for revised physical activity guidelines and protein intake recommendations that maximise healthspan.Frontiers in nutrition · 2026Article
- The gut microbiota-inflammageing axis in cardiometabolic health of older adults and dietary intervention strategies.Frontiers in nutrition · 2026Review
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Authors and funding
12 authors.
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Abstract
Background: Although protein supplementation may be desirable in the management of sarcopenia, the appropriate protein requirements for older adults with sarcopenia are presently unclear. Objective: The aim of this study was to determine the protein requirements of older adults (65-81 year) with sarcopenia by using the indicator amino acid oxidation (IAAO) technology. Methods: Nine older adults with sarcopenia (four male participants and five female participants) participated in the study, with protein intakes ranging from 0.1 to 1.8 g/(kg·d). Each participant consumed an adapted diet with a protein level of 1.0 g/(kg·d) and 1.7 resting energy expenditure (REE) for 2 day. Day 3 was the oxidation day of the study. Diets that delivered energy at a 1.5 × REE were isocaloric. The amounts of phenylalanine and tyrosine maintained at a constant across intakes. Therefore, phenylalanine and tyrosine were added to the protein doses of 0.1-1.5 g/kg, which was based on the highest dose of lactalbumin content [1.8 g/(kg·d)]. Applying a non-linear mixed-effects model analysis of F Results: The mean estimated average requirement (EAR) and recommended nutrient intake (RNI) of protein for older adults with sarcopenia were 1.21 (95% CI: 0.95, 1.46) and 1.54 (95% CI: 1.13, 1.95) g/(kg·d), respectively. Conclusions: To our knowledge, this is the first study of protein intake in older adults with sarcopenia and indicates that older adults with sarcopenia may require a higher intake of dietary protein. Clinical trial registration: http://www.chictr.org.cn, ChiCTR2200061383.
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