Evidence map›Paper›PMID 40093876›Full record

ArticleEuropean journal of radiology open2025

Neurochemical characteristics of pathological tissues in epilepsy: A preliminary

Lijing Xin, Philippe Reymond, José Boto, Frederic Grouiller, Serge Vulliemoz, Francois Lazeyras, Maria Isabel Vargas

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PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of radiology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lijing XinCenter for Biomedical Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Philippe ReymondDivision of Neuroradiology, Geneva University Hospitals and University of Geneva, Switzerland.
José BotoDivision of Neuroradiology, Geneva University Hospitals and University of Geneva, Switzerland.
Frederic GrouillerSwiss Center of Affective Sciences, University of Geneva, Switzerland.
Serge VulliemozDivision of Neurology, Neurosciences Department of Geneva University Hospitals and University of Geneva, Switzerland.
Francois LazeyrasCenter for Biomedical Imaging of Geneva and University of Geneva, Switzerland.
Maria Isabel VargasClinique des Grangettes-Hirslanden and University of Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: This study aims to evaluate the neurochemical characteristics of pathological tissues by Methods: Thirteen patients with drug-resistant epilepsy and focal seizure successfully underwent MRS examinations at 7 T MRI scanners. Results: In comparison to the contralateral side, lesions in focal cortical dysplasia demonstrated significantly reduced macromolecule and N-acetyl aspartate, significantly increased total choline and glycine + myo-inositol, and a distinct reduction trend of glutamate. Conclusions: We conclude that performing MRS at high magnetic field offered the potential to reveal metabolic alterations in epilepsy lesions that may help to further understand the underlying pathophysiology of the disease.

Indexed as

7 TCortical dysplasiaEpilepsyMR spectroscopyNon lesional

Identifiers

PMID40093876
PMCPMC11910369

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.