Targeted inhibition of integrin αVβ3 induces cytotoxicity and suppresses migration ability in ovarian cancer cells and tumor spheroids.

I-Lun Hsin, Ling-Yen Chiu, Jiunn-Liang Ko, Po-Hui Wang, Pei-Ju Wu

Abstract read

In one paragraph

Article in International journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Epitranscriptomic Regulation of Platinum Resistance via the METTL3-ADAM23 Axis in Ovarian Cancer.Cells · 2026
Article
Distinct transcriptomic features of tumor and stromal cells in direct contact in luminal and triple-negative breast cancers.Exploration of targeted anti-tumor therapy · 2026
Article
Bioinspired RGD-Functionalized Gold Nanoparticles for Integrin-Driven Interaction with Melanoma Cells.International journal of nanomedicine · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

I-Lun HsinInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Ling-Yen ChiuInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Jiunn-Liang KoInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Po-Hui WangInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Pei-Ju WuInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer is a gynecological malignancy that has poor prognosis and high lethality. Integrin αVβ3 is highly expressed in solid cancer cells, including ovarian cancer, and is important in proliferation and cell migration. In this study, we performed two-dimensional (2D) and three‑dimensional (3D) cell culture systems to investigate the potential of integrin αVβ3 as a therapeutic target for ovarian cancer. Inhibition of integrin αVβ3 by

Indexed as

Integrin alphaVbeta3Ovarian NeoplasmsSnake VenomsApoptosisCell Line, TumorCell MovementCell ProliferationCell SurvivalCisplatinFemaleHumansRNA, Small InterferingSpheroids, CellularCilengitideCisplatinIntegrin alphaVbeta3RNA, Small InterferingSnake Venoms3D cell cultureCell migrationextracellular matrixIntegrin αVβ3ovarian cancer

Identifiers

PMID40093794

DOI10.7150/ijms.103141

PMCPMC11905266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.