ArticleToxicology reports2024
Safety assessment of female sexual hygiene product containing cannabidiol in new zealand white rabbit and clinical trial.
Article in Toxicology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cannabis is an herb known for its significant pharmacological effects. This study evaluated the safety of a female sexual hygiene product containing cannabidiol on the skin of experimental animals and humans. Irritation symptoms were tested using three female New Zealand white rabbits. In human trials, irritation and sensitivity symptoms were assessed in 30 healthy female volunteers. The results from the animal study indicated that body weight and clinical symptoms remained normal, with only slight irritation noted in the primary irritation index of the skin (PII = 0.6). In human trials, transepidermal water loss was observed during the induction phase but decreased over time. No abnormalities were found during the induction phase; however, irritation occurred during the challenge phase, which resolved after 8 h. It was concluded that the rinse-off product caused slight irritation when applied for more than 4 h in animals and 24 h in humans, which differs from its intended use of immediate rinse-off, where no irritation was observed.
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