Evidence map›Paper›PMID 40093581›Full record

ArticleBJR open2025

Outcomes with radiotherapy in multimodality treatment for hepatocellular carcinoma with portal vein tumour thrombosis.

Puja Sahai, Hanuman Prasad Yadav, Ashok Choudhury, Saggere Muralikrishna Shasthry, Ankur Jindal, Aprajita Mall, Amar Mukund, Yashwant Patidar, Mangu Srinivas Bharadwaj, Bangkim Chandra Khangembam and 3 more

Abstract read
In one paragraph

Article in BJR open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Puja SahaiDepartment of Radiation Oncology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.ORCID https://orcid.org/0000-0002-4714-7398
Hanuman Prasad YadavDepartment of Radiation Oncology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Ashok ChoudhuryDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Saggere Muralikrishna ShasthryDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Ankur JindalDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Aprajita MallDepartment of Radiation Oncology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Amar MukundDepartment of Interventional Radiology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Yashwant PatidarDepartment of Interventional Radiology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.ORCID https://orcid.org/0000-0003-0420-3190
Mangu Srinivas BharadwajDepartment of Nuclear Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Bangkim Chandra KhangembamDepartment of Nuclear Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Guresh KumarDepartment of Biostatistics, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Archana RastogiDepartment of Pathology, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
Viniyendra PamechaDepartment of Hepatopancreatobiliary and Liver Transplant Surgery, Institute of Liver and Biliary Sciences, New Delhi 110070, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The purpose of the present study was to evaluate outcomes with radiation therapy (RT) in multimodality treatment for inoperable hepatocellular carcinoma (HCC) with portal vein tumour thrombosis (PVTT). Methods: The present retrospective study included 24 patients without extrahepatic metastases. The patients had received drug eluting beads - transarterial chemoembolization (DEB-TACE) ( Results: The disease control rate in PVTT was 50% at 3 months. The median overall survival (OS) was 10.9 months (95% CI, 0.74-21) for all patients. The 6-month, 1-year, 2-year, and 3-year OS rates were 75%, 45.8%, 25%, and 12.5%, respectively. The median OS was 30.4 months (95% CI, 12.1-48.7) versus 18.1 months (0.00-38.8) with complete or partial response versus stable or progressive disease in PVTT ( Conclusions: The present study showed the benefit of radiotherapy with systemic therapy and DEB-TACE in patients with HCC with PVTT. Advances in knowledge: Radiotherapy as part of the multimodality treatment offers the potential to improve disease control and survival in patients with HCC with PVTT.

Indexed as

hepatocellular carcinomaimmune checkpoint inhibitorsradiotherapytherapeutic chemoembolizationthrombosistyrosine kinase inhibitors

Identifiers

PMID40093581
PMCPMC11909637

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.