ArticleFrontiers in cellular and infection microbiology2025
Characterization of the gut microbiota in urinary calculi patients with preoperative urinary tract infection.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Clinical features ofFrontiers in cellular and infection microbiology · 2026Article
- Identifying urosepsis risk in diabetic patients with renal and ureteral calculi: Key predictors and clinical implications.World journal of diabetes · 2025Article
- Risk factors for urosepsis in diabetic patients with renal and ureteral calculi: A retrospective study.World journal of diabetes · 2025Article
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14 authors.
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Abstract
Background: Urinary tract infection is one of the most common comorbidities of urinary stones. Disorders of gut microbiota can affect various infectious diseases and the formation of the stones. Therefore, alterations in the gut bacteria profile may be a potential risk factor for the development of infections in patients with urinary tract stones. Methods: We conducted a retrospective study to analyze the association of urinary tract infections with gut microbiota and serum metabolism in patients with stones. Results: Patients with urolithiasis were predominantly in combination with diabetes mellitus (11.4% vs. 20%) and hypertension (36.4% vs. 50%). There were no statistically significant differences in hematological and urinary parameters. Compared to negative patients, IL-17A was significantly higher in the positive group (25.0 vs 21.1 pg/ml p = 0.038). The majority of pathogens detected in urine cultures were urease-negative bacteria, and urease-positive bacteria accounted for 15% of the total number of patients. We analyzed the community composition of the two groups of patients and found a significant difference in their β-diversity (p = 0.025), suggesting that dysbiosis of the gut bacteria may be associated with the combination of urinary tract infections in urolithiasis. For identification of crucial bacteria, we found changes in the abundance of both Conclusion: Urolithiasis with gut dysbiosis developed a higher incidence of urinary tract infections, which may be associated with the increasing of
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