Anti-lymphoma peptide is inspired by mapping a sequence of four amino acids of KRAI motif as nuclear localization signal of Crlz-1.

Joo Hyun Pi, Seung Young Choi, Sung-Kyun Park, Junghyun Lim, Chang Joong Kang

Abstract read

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Article in Molecular therapy. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors.

Joo Hyun PiDepartment of Genetics and Biotechnology, College of Life Sciences, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin, Gyeonggi 17104, South Korea.

Seung Young ChoiDepartment of Genetics and Biotechnology, College of Life Sciences, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin, Gyeonggi 17104, South Korea.

Sung-Kyun ParkInfectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, South Korea.

Junghyun LimSchool of Pharmacy and Institute of New Drug Development, Jeonbuk National University, Jeonju 54896, South Korea.

Chang Joong KangDepartment of Genetics and Biotechnology, College of Life Sciences, Kyung Hee University, 1732 Deogyeong-daero, Giheung, Yongin, Gyeonggi 17104, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptides of Crlz-1 nuclear localization signal as mapped to be a short KRAI sequence inhibited the proliferation of germinal center-derived Ramos cells from Burkitt's lymphoma patient. This anti-proliferative effect was mechanistically explained by a cascade of the block of Crlz-1 nuclear movement and consequential failure of CBFβ nuclear mobilization, resulting in the absence of bound Runx/CBFβ heterodimer on the enhancer-promoter of the

Indexed as

B cell lymphomaBcl-6Crlz-1MT: Regular Issuenuclear localization signalRunx/CBFβ

Identifiers

PMID40093512

DOI10.1016/j.omton.2025.200953

PMCPMC11906403

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