ReviewJAAD international2025
Treatment of Merkel cell carcinoma in organ transplant recipients-A systematic review.
Review in JAAD international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Skin Cancer in Solid Organ Transplant Recipients: A Review.American journal of clinical dermatology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There are no clear treatment guidelines for solid organ transplantation (SOT) patients with Merkel cell carcinoma (MCC) despite increased incidence rates. Objective: To review treatment outcomes of MCC patients with prior SOT. Methods: A systematic review (Prospective Register of Systematic Reviews CRD42024569200) of studies that reported treatment modalities and outcomes for MCC patients with SOT were selected. Databases screened included PubMed, Web of Science, Scopus, and Embase. Results: Thirty articles comprising 21 case reports, 8 cohort studies, and 1 clinical trial were included. Treatment modalities reported in case reports and clinical trials included surgery (77.7%), radiotherapy (62.9%), and chemotherapy (25.9%), with 3 patients receiving immune checkpoint inhibitors and 1 patient receiving an oncolytic virus. Cohort studies reported varying usage of surgery, radiotherapy, chemotherapy, and immunosuppression regime modifications. Limitations: Heterogeneity in methodologies and data reporting of studies included impeded meaningful comparisons. Lack of stratification of immunosuppressed populations in the excluded studies reduced the available patient data for comparison. Conclusion: Oncolytic virotherapy has the potential to mediate a localized, targeted response with minimal side effects in SOT patients. Inclusion of SOT patients with MCC into future clinical trials involving immunotherapy and immunosuppression combination therapies is needed to establish future treatment guidelines.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.