Evidence map›Paper›PMID 40093319›Full record

ArticleFrontiers in pharmacology2025

Administration of the K

O Daniel Vera, Ramesh C Mishra, Rayan Khaddaj-Mallat, Liam Hamm, Barak Almarzouq, Yong-Xiang Chen, Darrell D Belke, Latika Singh, Heike Wulff, Andrew P Braun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

O Daniel VeraDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Ramesh C MishraDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Rayan Khaddaj-MallatDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Liam HammDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Barak AlmarzouqDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Yong-Xiang ChenLibin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Darrell D BelkeLibin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Latika SinghDepartment of Pharmacology, School of Medicine, University of California Davis, Davis, CA, United States.
Heike WulffDepartment of Pharmacology, School of Medicine, University of California Davis, Davis, CA, United States.
Andrew P BraunDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Atherosclerosis remains a major risk factor for vascular dysfunction and cardiovascular (CV) disease. Pharmacological enhancement of endothelial Ca Methods: Male apolipoprotein E knockout (Apoe Results: Endothelium-dependent relaxation of phenylephrine-constricted aortic rings was impaired in Apoe Conclusion: Our data show that prolonged administration of the K

Indexed as

aortaApoE knockout mouseatherosclerosisendothelial dysfunctionKCa channel activator

Identifiers

PMID40093319
PMCPMC11906683

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.