ArticleBioactive materials2025
Living joint prosthesis with in-situ tissue engineering for real-time and long-term osteoarticular reconstruction.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Silk Fibroin-Modified Titanium Implants for Bone Tissue Engineering: Structural Basis, Functionalization and Composite Strategies.Macromolecular bioscience · 2026Review
- Hydrogels as Local Structural-Protective Platforms in Rheumatoid Arthritis: An Evidence-Graded Review Across the Synovium-Cartilage-Bone Axis.Gels (Basel, Switzerland) · 2026Review
- Bioinspired scaffold recapitulating chondrogenic ontogeny and microenvironment for functional cartilage regeneration.Bioactive materials · 2026Article
- Biomimetic hydrogel micro-/nanofibers forBioactive materials · 2026Review
- The application of tissue engineering in cartilage regeneration: technological advances and future challenges.Frontiers in bioengineering and biotechnology · 2026Review
- 3D bioprinted scaffolds for osteochondral regeneration: advancements and applications.Materials today. Bio · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The reconstruction of large osteoarticular defects caused by tumor resection or severe trauma remains a clinical challenge. Current metal prostheses exhibit a lack of osteo-chondrogenic functionality and demonstrate poor integration with host tissues. This often results in complications such as abnormal bone absorption and prosthetic loosening, which may necessitate secondary revisions. Here, we propose a paradigm-shifting "living prosthesis" strategy that combines a customized 3D-printed hollow titanium humeral prosthesis with engineered bone marrow condensations presenting bone morphogenetic protein-2 (BMP-2) and transforming growth factor-β3 (TGF-β3) from encapsulated silk fibroin hydrogels. This innovative approach promotes
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.