ArticleWorld journal of diabetes2025
Association between serum retinol-binding protein and lower limb atherosclerosis risk in type 2 diabetes mellitus.
Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSerum retinol-binding protein (RBP) is the primary transport protein of circulating vitamin A. RBP has a crucial role in maintaining nutrient metabolism and physiologic homeostasis. Several studies have indicated that serum RBP participates in the progression of diabetes and diabetes-related complications. However, the impact of serum RBP on lower limb atherosclerosis has not been determined in individuals with type 2 diabetes mellitus (T2DM).
aimTo determine the association between serum RBP and lower limb atherosclerosis in individuals with T2DM.
methodsThis retrospective study enrolled 4428 eligible T2DM patients and divided the patients into non-lower limb atherosclerosis (
resultsAmong 4428 individuals with T2DM, 2515 (56.80%) had lower limb atherosclerosis. Logistic analysis showed that lower limb atherosclerosis risk increased by 1% for every 1 unit rise in serum RBP level (odds ratio = 1.01, 95% confidence interval: 1.00-1.02,
conclusionElevated serum RBP levels correlate with an increased lower limb atherosclerosis risk in individuals with T2DM.
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