Evidence map›Paper›PMID 40093261›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Physical activity and

Eli G Blum, Kyle J Edmunds, Brianne Breidenbach, Noah Cook, Ira Driscoll, Sarah R Lose, Barbara B Bendlin, Yue Ma, Bradley Christian, Tobey J Betthauser and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eli G BlumWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Kyle J EdmundsWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Brianne BreidenbachWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Noah CookWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Ira DriscollWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Sarah R LoseWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Barbara B BendlinWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Yue MaWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Bradley ChristianDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Tobey J BetthauserWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Mark SagerWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Sanjay AsthanaWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.
Dane B CookGeriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705.
Ozioma C OkonkwoWisconsin Alzheimer's Disease Research Center and Department of Geriatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792.

Funding

Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
The Longitudinal Course of Neural Function and Amyloid in People At Risk for ADR01AG021155 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson · 2004 to 2026
$27.0M
Wisconsin Registry for Alzheimer's PreventionRF1AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, STERLING C · 2018 to 2018
$18.8M
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
Longitudinal Investigation of Cardiorespiratory Fitness and AD Biomarkers in an At-Risk CohortR01AG062167 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI OKONKWO, OZIOMA C · 2019 to 2023
$4.5M
KLOTHO and Resilience to Synaptic Dysfunction in Preclinical ADR01AG077507 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Ira Frahmand, Ozioma C Okonkwo · 2023 to 2026
$3.1M
Sleep and Aerobic Fitness as Midlife Modifiers of Later Life Cognitive Decline and Alzheimer's Disease Biomarkers in the Wisconsin Sleep CohortR01AG085592 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Ozioma C Okonkwo, PAUL E PEPPARD · 2024 to 2026
$2.3M
High Performance Gradient System for Advanced Neuroimaging ResearchS10OD030415 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI ALEXANDER, ANDREW L · 2021 to 2021
$2.0M
CSRD VA IK6 CX002369NCRR NIH HHS UL1 RR025011NIA NIH HHS P30 AG062715NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG054059NIA NIH HHS R01 AG062167NIA NIH HHS R01 AG077507NIA NIH HHS R01 AG085592NIA NIH HHS RF1 AG027161NICHD NIH HHS P50 HD105353NIH HHS S10 OD030415
6 · The paper itself

Abstract

Background: Physical activity (PA) is a protective factor against amyloid-β (Aβ) accumulation in adults at risk for Alzheimer's disease (AD). This association, however, may differ by apolipoprotein E ( Materials and Methods: Included were 388 cognitively unimpaired, older (mean age ± SD = 68.10 ± 7.09; 66% female) participants from the Wisconsin Registry for Alzheimer's Prevention (WRAP) study. The cohort was enriched with both family history of AD at enrollment and a higher overall prevalence of Results: Three-way interactions (Age × PA × Conclusion: Individuals with high

Identifiers

PMID40093261
PMCPMC11908305

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.