Evidence map›Paper›PMID 40093253›Full record

ArticlemedRxiv : the preprint server for health sciences2025

David Hodgson, James Hay, Sheikh Jarju, Dawda Jobe, Rhys Wenlock, Thushan I de Silva, Adam J Kucharski

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

David HodgsonCentre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine.ORCID 0000-0002-5585-8974
James HayPandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford.ORCID 0000-0002-1998-1844
Sheikh JarjuVaccines and Immunity Theme, MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine.
Dawda JobeVaccines and Immunity Theme, MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine.
Rhys WenlockVaccines and Immunity Theme, MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine.
Thushan I de SilvaVaccines and Immunity Theme, MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine.ORCID 0000-0002-6498-9212
Adam J KucharskiCentre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine.

Funding

Does repeated influenza vaccination constrain influenza immune responses and protection?R01AI141534 · NIAID · UNIVERSITY OF MELBOURNE · PI FOX, ANNETTE, KUCHARSKI, ADAM JAMES · 2019 to 2023
$4.9M
NIAID NIH HHS R01 AI141534Wellcome Trust
6 · The paper itself

Abstract

Understanding acute infectious disease dynamics at individual and population levels is critical for informing public health preparedness and response. Serological assays, which measure a range of biomarkers relating to humoral immunity, can provide a valuable window into immune responses generated by past infections and vaccinations. However, traditional methods for interpreting serological data, such as binary seropositivity and seroconversion thresholds, often rely on heuristics that fail to account for individual variability in antibody kinetics and timing of infection, potentially leading to biased estimates of infection rates and post-exposure immune responses. To address these limitations, we developed

Indexed as

antibody kineticsBayesian modelingepidemiologyinfection dynamicspublic healthSARS-CoV-2Serological inference

Identifiers

PMID40093253
PMCPMC11908275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.