Evidence map›Paper›PMID 40093252›Full record

ArticlemedRxiv : the preprint server for health sciences2025

The impact of cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline.

A J Paulsen, I Driscoll, B M Breidenbach, M P Glittenberg, S R Lose, Y Ma, M A Sager, C M Carlsson, C L Gallagher, B P Hermann and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

A J PaulsenWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
I DriscollWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
B M BreidenbachWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
M P GlittenbergWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
S R LoseWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
Y MaWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
M A SagerWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
C M CarlssonWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
C L GallagherGeriatric Research Education and Clinical Center, William S. Middleton VA Hospital, 2500 Overlook Terrace, Madison, Wisconsin, USA, 53705.
B P HermannWisconsin Alzheimer's Institute, 610 Walnut St, Suite 957, Madison, Wisconsin, 53726, USA.
K BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Box 100, 405 30 Gothenburg, Mölndal, Sweden.
H ZetterbergWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
S AsthanaWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
S C JohnsonWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
T J BetthauserWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.
B T ChristianDepartment of Medical Physics, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 111 Highland Ave, Room 1005, Madison, Wisconsin, USA, 53705.
D B CookWilliam S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, Wisconsin, USA, 53705.
O C OkonkwoWisconsin Alzheimer's Disease Research Center, Department of Medicine, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, MC2420, Madison, Wisconsin, 53792, USA.

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
Wisconsin Registry for Alzheimer's PreventionRF1AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, STERLING C · 2018 to 2018
$18.8M
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
Longitudinal Investigation of Cardiorespiratory Fitness and AD Biomarkers in an At-Risk CohortR01AG062167 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI OKONKWO, OZIOMA C · 2019 to 2023
$4.5M
Sleep and Aerobic Fitness as Midlife Modifiers of Later Life Cognitive Decline and Alzheimer's Disease Biomarkers in the Wisconsin Sleep CohortR01AG085592 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Ozioma C Okonkwo, PAUL E PEPPARD · 2024 to 2026
$2.3M
High Performance Gradient System for Advanced Neuroimaging ResearchS10OD030415 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI ALEXANDER, ANDREW L · 2021 to 2021
$2.0M
CSRD VA IK6 CX002369NCATS NIH HHS UL1 TR002373NIA NIH HHS P30 AG062715NIA NIH HHS R01 AG054059NIA NIH HHS R01 AG062167NIA NIH HHS R01 AG085592NIA NIH HHS RF1 AG027161NICHD NIH HHS P50 HD105353NIH HHS S10 OD030415
6 · The paper itself

Abstract

introductionRelationships between core Alzheimer's disease (AD) biomarker accumulation and cognitive decline are well-established and the literature generally suggests a favorable relationship of cardiorespiratory fitness (CRF) on AD biomarker accumulation and cognition. Differences in risk of biomarker status conversion or accumulation rates by CRF, or their potential interactive relationships with cognitive decline remain largely unknown.

methodsParticipants (N=533; Mean

resultsNo significant relationships were observed between eCRF and biomarker trajectories. However, those in the high eCRF group who were also Aβ- (HR[95%CI]=0.42[0.20, 0.88]) and pTau-217-(HR[95%CI]=0.45[0.21, 0.97]) at baseline had a significantly lower risk of becoming biomarker-positive. There was a significant attenuation of the detrimental relationship between Aβ accumulation and cognitive decline for those with high eCRF and Aβ+/T+. DISCUSSION: While CRF did not influence core AD biomarker accumulation trajectories, high CRF did seem to protect against becoming biomarker-positive and attenuate the known deleterious relationship between biomarker accumulation and cognitive decline in Aβ+/T+.

Indexed as

Alzheimer’s diseasebiomarkerscardiorespiratory fitnessexercisephysical activity

Identifiers

PMID40093252
PMCPMC11908334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.