ArticlemedRxiv : the preprint server for health sciences2025
SNP-Associated Differential Methylation in
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Objective: Associations have been seen between suicidal behavior and differential DNA methylation of certain genes, with one study showing significant hypomethylation of Method: With pyrosequencing, we looked at the previously identified region of interest in Results: None of the CpG sites measured had an association between groups, although there were distinct clusters of differential methylation in each group. Applying genotypes of SNPs found in the region of interest, rs2121558 and rs1447093, these clusters showed stepwise methylation at each CpG site, regardless of phenotype. Conclusions: In this relatively small sample size study, differential methylation in Highlights:
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