Evidence map›Paper›PMID 40093200›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Distinguishing syndromic and nonsyndromic cleft palate through analysis of protein-altering de novo variants in 816 trios.

Kelsey R Robinson, Sarah W Curtis, Justin E Paschall, Terri H Beaty, Azeez Butali, Carmen J Buxó, David J Cutler, Michael P Epstein, Jacqueline T Hecht, Lina Moreno Uribe and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Kelsey R RobinsonDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA.
Sarah W CurtisDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA.
Justin E PaschallDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Terri H BeatyDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD.
Azeez ButaliDepartment of Oral Biology, Radiology, and Medicine, University of Iowa, Iowa City, IA.
Carmen J BuxóSchool of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico.
David J CutlerDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA.
Michael P EpsteinDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA.
Jacqueline T HechtDepartment of Pediatrics, McGovern Medical School University of Texas Health at Houston, Houston, TX.
Lina Moreno UribeDepartment of Orthodontics & The Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA.
Gary M ShawDepartment of Pediatrics, Stanford University, Stanford, CA.
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa, Iowa City, IA.
Harrison BrandCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA.
Seth M WeinbergCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Mary L MarazitaCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine; Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Kimberly F DohenyDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Elizabeth J Leslie-ClarksonDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA.

Funding

Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7M
Tracking and Evaluation CoreU54GM133807 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., MOROU-BERMUDEZ, EVANGELIA · 2020 to 2024
$17.7M
MOLECULAR STUDIES IN NONSYNDROMIC CLEFT LIP AND PALATER01DE011931 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BLANTON, SUSAN HALLORAN, HECHT, JACQUELINE T · 1999 to 2017
$7.6M
Whole Genome Sequencing for Orofacial Clefts, Incidental Findings and Role of Community GatekeepersR01DE028300 · NIDCR · UNIVERSITY OF IOWA · PI BUTALI, AZEEZ · 2020 to 2024
$3.9M
Integration of polygenic risk and facial morphometrics to decipher the genetic susceptibility of orofacial cleftingR01DE031261 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI Harrison Brand · 2022 to 2026
$3.8M
Genomics of Cleft PalateR01DE030342 · NIDCR · EMORY UNIVERSITY · PI ELIZABETH JANE LESLIE-CLARKSON · 2021 to 2026
$3.5M
Transfer 5R01DE027983 - Genomic and Functional Analysis of IRF6 Target Genes in Orofacial Cleft PathogenesisR01DE027983 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI LIAO, ERIC CHIEN-WEI · 2019 to 2023
$3.3M
Genetic modifiers of Van der Woude syndromeR01DE028342 · NIDCR · EMORY UNIVERSITY · PI LESLIE-CLARKSON, ELIZABETH JANE · 2019 to 2023
$2.7M
Investigating the role of genes, maternal exposures, and interactions on orofacial cleftsR01DE032122 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAFFER, JOHN R · 2022 to 2024
$2.1M
MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATER01DE008559 · NIDCR · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 1988 to 2003
$1.5M
Genetic and Environmental Risks for Oral Clefts in Puerto Rican HispanicsR00DE024571 · NIDCR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI BUXO, CARMEN J. · 2018 to 2021
$1.2M
NCBDD CDC HHS U01 DD001033NHLBI NIH HHS HHSN268201700006CNIDCR NIH HHS R00 DE024571NIDCR NIH HHS R01 DE008559NIDCR NIH HHS R01 DE011931NIDCR NIH HHS R01 DE016148NIDCR NIH HHS R01 DE027983NIDCR NIH HHS R01 DE028300NIDCR NIH HHS R01 DE028342NIDCR NIH HHS R01 DE030342NIDCR NIH HHS R01 DE031261NIDCR NIH HHS R01 DE032122NIGMS NIH HHS U54 GM133807
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40093200
PMCPMC11908282

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.