Evidence map›Paper›PMID 40093197›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Polygenic Scores for Dizygotic Twinning: Insights into the Genetic Architecture of Female Fertility.

Nikki Hubers, Christian M Page, René Pool, Hamdi Mbarek, Nils Lambalk, Velja Mijatovic, Lannie Ligthart, Jenny van Dongen, Elizabeth C Corfield, Jeffrey J Beck and 7 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Nikki HubersDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0001-6030-9235
Christian M PageCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-1897-3666
René PoolDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0001-5579-0933
Hamdi MbarekDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-1108-0371
Nils LambalkAmsterdam Reproduction & Development (AR&D) Research Institute, Amsterdam, the Netherlands.
Velja MijatovicAmsterdam Reproduction & Development (AR&D) Research Institute, Amsterdam, the Netherlands.ORCID 0000-0002-0435-9921
Lannie LigthartDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-6570-3319
Jenny van DongenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0003-2063-8741
Elizabeth C CorfieldNic Waals Institute, Lovisenberg Diaconal Hospital & PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health.ORCID 0000-0002-0119-157X
Jeffrey J BeckAvera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, USA.
Erik A EhliAvera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, USA.ORCID 0000-0002-7865-3015
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0003-3755-0236
Siri HåbergDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Jennifer R HarrisCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Jouke-Jan HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0002-5668-2368
Dorret I BoomsmaAmsterdam Reproduction & Development (AR&D) Research Institute, Amsterdam, the Netherlands.ORCID 0000-0002-7099-7972

Funding

Genomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8M
EPA EP-C-15-001NIMH NIH HHS RC2 MH089995
6 · The paper itself

Abstract

Natural dizygotic twinning (DZT) results from hyper-ovulation and is considered an indicator of female fertility. DZT has low polygenicity, with only 0.20% of SNPs estimated to have a nonzero effect. A polygenic score (PGS) for DZT explains 1.6% of variance in DZT liability and we observe an odds ratio of 2.29 between the 1

Indexed as

Dizygotic TwinningFemale FertilityMedically Assisted reproduction (MAR)Polygenic Scores (PGS)

Identifiers

PMID40093197
PMCPMC11908296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.