Evidence map›Paper›PMID 40093166›Full record

ArticlebioRxiv : the preprint server for biology2025

Engineered basement membrane mimetic hydrogels to study mammary epithelial morphogenesis and invasion.

Jane A Baude, Megan D Li, Sabrina M Jackson, Abhishek Sharma, Daniella I Walter, Ryan S Stowers

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jane A BaudeUniversity of California, Santa Barbara, Department of Molecular, Cellular, and Developmental Biology.
Megan D LiUniversity of California, Santa Barbara, Department of Molecular, Cellular, and Developmental Biology.
Sabrina M JacksonUniversity of California, Santa Barbara, Department of Molecular, Cellular, and Developmental Biology.
Abhishek SharmaUniversity of California, Santa Barbara, Department of Mechanical Engineering.
Daniella I WalterUniversity of California, Santa Barbara, Department of Mechanical Engineering.
Ryan S StowersUniversity of California, Santa Barbara, Department of Molecular, Cellular, and Developmental Biology.ORCID 0000-0002-0741-7103

Funding

Predoctoral Training Program in Quantitative MechanobiologyT32GM141846 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Siddharth Subhas Dey, Beth L Pruitt · 2021 to 2026
$1.9M
NIGMS NIH HHS T32 GM141846
6 · The paper itself

Abstract

Reconstituted basement membrane (rBM) products like Matrigel are widely used in 3D culture models of epithelial tissues and cancer. However, their utility is hindered by key limitations, including batch variability, xenogenic contaminants, and a lack of tunability. To address these challenges, we engineered a 3D basement membrane (eBM) matrix by conjugating defined extracellular matrix (ECM) adhesion peptides (IKVAV, YIGSR, RGD) to an alginate hydrogel network with precisely tunable stiffness and viscoelasticity. We optimized the mechanical and biochemical properties of the engineered basement membranes (eBMs) to support mammary acinar morphogenesis in MCF10A cells, similar to rBM. We found that IKVAV-modified, fast-relaxing (τ1

Identifiers

PMID40093166
PMCPMC11908212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.