Evidence map›Paper›PMID 40093159›Full record

ArticlebioRxiv : the preprint server for biology2025

MHCII reduction is insufficient to protect mice from alpha-synuclein-induced degeneration and the Parkinson's HLA locus exhibits epigenetic regulation.

Elizabeth M Kline, Janna E Jernigan, Christopher D Scharer, Jeffrey Maurer, Sakeenah Hicks Sl, Mary K Herrick M, Rebecca L Wallings, Sean D Kelly, Jianjun Chang, Kelly B Menees and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Elizabeth M KlineDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT USA.
Janna E JerniganDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL USA.ORCID 0000-0003-0771-384X
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA USA.ORCID 0000-0001-7716-8504
Jeffrey MaurerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA USA.
Sakeenah Hicks SlDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA USA.
Mary K Herrick MDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL USA.ORCID 0000-0002-7284-9762
Rebecca L WallingsDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL USA.ORCID 0000-0003-0947-4459
Sean D KellyDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0003-4282-8546
Jianjun ChangDepartment of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA.
Kelly B MeneesDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL USA.
Nikolaus R McFarlandDepartment of Neurology, University of Florida College of Medicine, Gainesville, FL USA.ORCID 0000-0002-8699-8857
Jeremy M BossDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA USA.ORCID 0000-0002-2432-1840
Malú Gámez TanseyDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL USA.ORCID 0000-0002-1719-4708
Valerie JoersDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL USA.ORCID 0000-0001-6743-6587

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Social Determinants of Health, Race/Ethnicity, and White Matter HyperintensitiesP30AG066506 · NIA · UNIVERSITY OF FLORIDA · PI Rosie E Curiel Cid · 2020 to 2026
$25.6M
Udall Parkinson's Disease Center at Emory University: Circuitry to TherapyP50NS071669 · NINDS · EMORY UNIVERSITY · PI WICHMANN, THOMAS · 2010 to 2015
$6.8M
Role of central and peripheral immune crosstalk in FTD-Grn neurodegenerationRF1NS128800 · NINDS · UNIVERSITY OF FLORIDA · PI FINKBEINER, STEVEN M, TANSEY, MARIA DE LOURDES GAMEZ · 2022 to 2022
$2.4M
Role of the DR/DQ super enhancer in MHC-II expressionR01AI153102 · NIAID · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 2020 to 2024
$2.4M
Role of HLA/MHCII in Parkinson's Disease PathogenesisR01NS092122 · NINDS · EMORY UNIVERSITY · PI BOSS, JEREMY M., TANSEY, MARIA DE LOURDES GAMEZ · 2015 to 2019
$1.8M
NCRR NIH HHS UL1 RR025008NIAID NIH HHS R01 AI153102NIA NIH HHS P30 AG066506NINDS NIH HHS P50 NS071669NINDS NIH HHS R01 NS092122NINDS NIH HHS RF1 NS128800
6 · The paper itself

Abstract

Major histocompatibility complex class II (MHCII) molecules are antigen presentation proteins and increased in post-mortem Parkinson's disease (PD) brain. Attempts to decrease MHCII expression have led to neuroprotection in PD mouse models. Our group reported that a SNP at

Indexed as

alpha-synucleinAntigen presentationHLAMHCIImicrogliaParkinson’s diseaseT cells

Identifiers

PMID40093159
PMCPMC11908218

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.