Evidence map›Paper›PMID 40093153›Full record

ArticlebioRxiv : the preprint server for biology2025

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated

Jingliang Zhang, Muriel Eaton, Xiaoling Chen, Yuanrui Zhao, Shivam Kant, Brody A Deming, Kothandaraman Harish, Huynhvi P Nguyen, Yue Shu, Shirong Lai and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jingliang ZhangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.ORCID 0000-0002-2903-1287
Muriel EatonBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Xiaoling ChenBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Yuanrui ZhaoBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Shivam KantBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Brody A DemingBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Kothandaraman HarishDepartment of Comparative Pathobiology, Purdue University.
Huynhvi P NguyenBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Yue ShuBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Shirong LaiBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Jiaxiang WuBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Zhefu QueBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Kyle W WettschurackBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Zaiyang ZhangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Tiange XiaoBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Manasi S HalurkarBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Maria I Olivero-AcostaBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Ye-Eun YooBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.
Nadia A LanmanDepartment of Comparative Pathobiology, Purdue University.
Wendy A KossPurdue Institute for Integrative Neuroscience, Purdue University.
William C SkarnesThe Jackson Laboratory for Genomic Medicine.
Yang YangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University.ORCID 0000-0001-6417-3654

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3M
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Neuronal and Behavioral Deficits Associated with Scn2a Deficiency in Autism Spectrum DisorderR01NS117585 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$2.0M
Neuronal hyperexcitability and seizures in a Scn2a deficient mouse modelR01NS123154 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$1.9M
NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA023168NCI NIH HHS P30 CA082709NINDS NIH HHS R01 NS117585NINDS NIH HHS R01 NS123154
6 · The paper itself

Abstract

Social behavior is critical for survival and adaptation, which is profoundly disrupted in autism spectrum disorders (ASD). Social withdrawal due to information overload was often described in ASD, and it was suspected that increased basal noise, i.e., excessive background neuronal activities in the brain could be a disease mechanism. However, experimental test of this hypothesis is limited. Loss-of-function mutations (deficiency) in

Indexed as

autismbrain organoidE/I imbalanceSCN2A/Scn2asignal-to-noise ratiosociabilityvoltage-gated sodium channel

Identifiers

PMID40093153
PMCPMC11908182

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.