Evidence map›Paper›PMID 40093141›Full record

ArticlebioRxiv : the preprint server for biology2025

Monitoring mutant myocilin secretion and localization in trabecular meshwork cell cultures using a protein complementation-based luminescence assay.

Hannah A Youngblood, Ethan F Harris, Kaylee P Lankford, Victoria Garfinkel, John D Hulleman, Raquel L Lieberman

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Hannah A YoungbloodSchool of Chemistry & Biochemistry, Georgia Institute of Technology.
Ethan F HarrisSchool of Chemistry & Biochemistry, Georgia Institute of Technology.
Kaylee P LankfordDepartment of Ophthalmology, University of Texas Southwestern Medical Center.
Victoria GarfinkelDepartment of Ophthalmology, University of Texas Southwestern Medical Center.
John D HullemanDepartment of Ophthalmology, University of Texas Southwestern Medical Center.
Raquel L LiebermanSchool of Chemistry & Biochemistry, Georgia Institute of Technology.ORCID 0000-0001-9345-3735

Funding

Request for Supplement to Promote Diversity in Health Related ResearchR01EY021205 · NEI · GEORGIA INSTITUTE OF TECHNOLOGY · PI Raquel L Lieberman · 2011 to 2026
$6.8M
VIsion Science Training in AtlantaT32EY007092 · NEI · EMORY UNIVERSITY · PI Machelle T. Pardue · 1985 to 2026
$4.6M
T35 NEI Medical Student Summer Research TrainingT35EY026510 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI Benjamin Franklin Chong, DANIELLE M. ROBERTSON · 2018 to 2026
$99k
NEI NIH HHS R01 EY021205NEI NIH HHS T32 EY007092NEI NIH HHS T35 EY026510
6 · The paper itself

Abstract

Approximately 2-4% of adult onset and 10% of juvenile onset cases of primary open angle glaucoma can be attributed to non-synonymous coding mutations in

Indexed as

cellular traffickingglaucomaimmunoblotimmunofluorescenceluminescencemisfoldingmyocilinsecretion

Identifiers

PMID40093141
PMCPMC11908155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.