Evidence map›Paper›PMID 40093137›Full record

ArticlebioRxiv : the preprint server for biology2025

Independent signaling pathways provide a fail-safe mechanism to prevent tumorigenesis.

Sari Anschütz, Andrea Schubert, Jobelle M Peralta, Todd G Nystul, Katja Rust

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sari AnschützInstitute of Physiology and Pathophysiology, Dept. of Molecular Cell Physiology, Philipps University Marburg, Germany.
Andrea SchubertInstitute of Physiology and Pathophysiology, Dept. of Molecular Cell Physiology, Philipps University Marburg, Germany.
Jobelle M PeraltaUCSF, Department of Anatomy, 513 Parnassus Ave, San Francisco, CA 94143, USA.
Todd G NystulUCSF, Department of Anatomy, 513 Parnassus Ave, San Francisco, CA 94143, USA.ORCID 0000-0002-6250-2394
Katja RustInstitute of Physiology and Pathophysiology, Dept. of Molecular Cell Physiology, Philipps University Marburg, Germany.ORCID 0000-0001-6367-5994

Funding

Cell Fate Decisions in Epithelial Stem Cell LineagesR35GM136348 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 2020 to 2026
$3.9M
NIGMS NIH HHS R35 GM136348
6 · The paper itself

Abstract

Controlled signaling activity is vital for normal tissue homeostasis and oncogenic signaling activation facilitates tumorigenesis. Here we use single-cell transcriptomics to investigate the effects of pro-proliferative signaling on epithelial homeostasis using the

Identifiers

PMID40093137
PMCPMC11908167

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.