Evidence map›Paper›PMID 40093134›Full record

ArticlebioRxiv : the preprint server for biology2025

Engineering gene drive docking sites in a haplolethal locus in

Andrea L Smidler, Eryney A Marrogi, Sean Scott, Enzo Mameli, Daniel Abernathy, Omar S Akbari, George M Church, Flaminia Catteruccia, Kevin Esvelt

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Andrea L SmidlerDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-3281-1161
Eryney A MarrogiDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Sean ScottDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Enzo MameliDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-0172-8090
Daniel AbernathyDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-0361-3147
Omar S AkbariSchool of Biological Sciences, Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6853-9884
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6232-9969
Flaminia CatterucciaDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-3295-6683
Kevin EsveltMedia Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-8797-3945

Funding

The olfactory basis of locating nectar sugar sources in Aedes aegypti mosquitoesR01AI148300 · NIAID · UNIVERSITY OF WASHINGTON · PI Omar Sultan Akbari, Ronald Jason Pitts · 2021 to 2026
$4.1M
Olfactory modulation of color vision and behavior in mosquitoesR01AI175152 · NIAID · UNIVERSITY OF WASHINGTON · PI Omar Sultan Akbari, Jeffrey A Riffell · 2023 to 2026
$3.2M
Targeting the reproductive interactome of the malaria vector Anopheles gambiaeR01AI104956 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI CATTERUCCIA, FLAMINIA · 2013 to 2017
$3.0M
Precision guided SIT for the control of vector-borne diseaseR01AI151004 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKBARI, OMAR SULTAN · 2020 to 2024
$2.3M
Sculpting the Enteric Microbiota with CRISPR-Cas SystemsR00DK102669 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESVELT, KEVIN · 2016 to 2017
$496k
Using genome engineering to study mosquito biology and combat malariaF31AI120480 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI SMIDLER, ANDREA LYNELLE · 2016 to 2018
$74k
NIAID NIH HHS F31 AI120480NIAID NIH HHS R01 AI104956NIAID NIH HHS R01 AI148300NIAID NIH HHS R01 AI151004NIAID NIH HHS R01 AI175152NIDDK NIH HHS R00 DK102669
6 · The paper itself

Abstract

Gene drives are selfish genetic elements which promise to be powerful tools in the fight against vector-borne diseases such as malaria. We previously proposed population replacement gene drives designed to better withstand the evolution of resistance by homing through haplolethal loci. Because most mutations in the wild-type allele that would otherwise confer resistance are lethal, only successful drive homing permits the cell to survive. Here we outline the development and characterization of two ΦC31-Recombination mediated cassette exchange (RMCE) gene drive docking lines with these features in

Identifiers

PMID40093134
PMCPMC11908198

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.