Evidence map›Paper›PMID 40093132›Full record

ArticlebioRxiv : the preprint server for biology2025

The organizer as a cooperative of signaling cells for neural induction.

Hui-Chun Lu, Katherine E Trevers, Tatiana Solovieva, Claire Anderson, Linette Pérez-Campos, Lenka Filipkova, Vlad Arimia, Charlotte Colle, Nidia M M De Oliveira, Leslie Dale and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hui-Chun LuDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Katherine E TreversDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Tatiana SolovievaDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.ORCID 0000-0001-6194-2550
Claire AndersonDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Linette Pérez-CamposDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Lenka FilipkovaDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Vlad ArimiaDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Charlotte ColleDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Nidia M M De OliveiraDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Leslie DaleDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Claudio D SternDepartment of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.ORCID 0000-0002-9907-889X

Funding

EARLY EVENTS IN NEURAL AND HOMEOGENETIC INDUCTIONR01MH060156 · NIMH · UNIVERSITY COLLEGE LONDON · PI STERN, CLAUDIO D · 1999 to 2005
$867k
NIMH NIH HHS R01 MH060156Wellcome Trust
6 · The paper itself

Abstract

The "organizer", discovered 100 years ago by Hans Spemann and Hilde Mangold, is a special region of vertebrate embryos at the gastrula stage; it emits signals that can re-direct the fate of neighboring cells to acquire neural plate identity. It is generally imagined as unique population of cells producing one or a few signaling molecules, responsible for neural induction and for patterning the neural plate and the mesoderm. Here we use single cell and tissue transcriptomics to explore the expression of signaling molecules in the node (the amniote organizer). Although all organizer cells express the homeobox gene

Indexed as

chick embryogastrulationHensen’s nodeMajor: Biological SciencesMinor: Developmental biologyprimitive streakSpemann-Mangold organizer

Identifiers

PMID40093132
PMCPMC11908251

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.