In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
17 authors.
Zinan ZhouDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.ORCID 0000-0003-2014-3650 Guanlan DongDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.ORCID 0000-0002-4747-6036 Jayoung KuDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.ORCID 0000-0002-4112-4582 Kisong KimDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.
Mingyun BaeDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.ORCID 0009-0000-8144-476X Diane D ShaoDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.ORCID 0000-0003-2087-4082 Michael B MillerDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.ORCID 0000-0002-6205-3314 August Yue HuangDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.ORCID 0000-0002-0416-2854 Andre NussenzweigLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Clotilde Lagier-TourenneDepartment of Neurology, Sean M. Healey & AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School; Boston, MA, USA.ORCID 0000-0002-3058-8322 Eunjung Alice LeeDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.
Christopher A WalshDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital; Boston, MA, USA.ORCID 0000-0002-0156-2238 Funding
Cell Identity Determination In Human Brain: Somatic Mutation and Cell LineageR01NS032457 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Alice Eunjung Lee, Christopher A. Walsh · 1995 to 2026
$12.7MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MRole of clonal somatic mutations in microglia and Alzheimer’s diseaseR01AG088082 · NIA · BOSTON CHILDREN'S HOSPITAL · PI Yue Huang · 2024 to 2026
$4.4MRates and mechanisms of age-related somatic mutation in normal and Alzheimer brainR01AG070921 · NIA · BOSTON CHILDREN'S HOSPITAL · PI LEE, ALICE EUNJUNG, WALSH, CHRISTOPHER A. · 2021 to 2025
$4.3MDevelopment and Application of Computational Methods for Single Cell DNA Sequencing DataR01HG012573 · NHGRI · HARVARD MEDICAL SCHOOL · PI PARK, PETER J · 2022 to 2025
$2.7MIlluminating neurodegenerative tauopathy from somatic genomic landscapes of single human brain cellsDP2AG086138 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B Miller · 2023 to 2026
$2.7MMechanisms of Somatic Mutation in Alzheimer's Disease Using Single Neuron AnalysisR01AG082346 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Michael B Miller · 2024 to 2026
$2.7MMechanism for endogenous retroelements to mimic ancient exogenous identities in aging and diseased human tissueDP2AG072437 · NIA · BOSTON CHILDREN'S HOSPITAL · PI LEE, EUNJUNG ALICE · 2020 to 2020
$2.7MRole of clonal somatic mutations in microglia activation and Alzheimer’s diseaseR56AG079857 · NIA · BOSTON CHILDREN'S HOSPITAL · PI HUANG, YUE, LEE, EUNJUNG ALICE · 2023 to 2023
$883kThe role of somatic mutation in neurodegenerative diseaseK01AG051791 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE, EUNJUNG ALICE · 2016 to 2020
$655kNHGRI NIH HHS R01 HG012573NIA NIH HHS DP2 AG072437NIA NIH HHS DP2 AG086138NIA NIH HHS K01 AG051791NIA NIH HHS R01 AG070921NIA NIH HHS R01 AG082346NIA NIH HHS R01 AG088082NIA NIH HHS R56 AG079857NICHD NIH HHS P50 HD105351NINDS NIH HHS R01 NS032457
6 · The paper itselfAbstract
Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer's disease (AD) are common neurodegenerative disorders for which the mechanisms driving neuronal death remain unclear. Single-cell whole-genome sequencing of 429 neurons from three
Identifiers
PMID40093130
PMCPMC11908196
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