Evidence map›Paper›PMID 40093125›Full record

ArticlebioRxiv : the preprint server for biology2025

Mutations and structural variants arising during double-strand break repair.

Simona Dalin, Sophie Webster, Neal Sugawara, Qiuqin Wu, Shu Zhang, Carmen Macias, Elena Sapède, Tracy Cui, Victoria Liang, Laura Tran and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Simona DalinCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-5024-9718
Sophie WebsterCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Neal SugawaraRosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454.
Qiuqin WuRosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454.
Shu ZhangCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Carmen MaciasRosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454.
Elena SapèdeRosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454.
Tracy CuiCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Victoria LiangRosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454.
Laura TranRosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454.
Rameen BeroukhimCancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
James E HaberRosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, Massachusetts 02454.ORCID 0000-0002-1878-0610

Funding

DNA Damage Response and Repair of a Broken ChromosomeR35GM127029 · NIGMS · BRANDEIS UNIVERSITY · PI JAMES E HABER · 2018 to 2026
$8.6M
Genetic evolution of glioblastomas during radiation and temozolomide therapyR01CA188228 · NCI · DANA-FARBER CANCER INST · PI BEROUKHIM, RAMEEN, CHAKRAVARTI, ARNAB · 2015 to 2025
$6.9M
Synthetic lethalities to cell cycle disruption in gliomaR01CA262462 · NCI · DANA-FARBER CANCER INST · PI RAMEEN BEROUKHIM, KEITH LLOYD LIGON · 2022 to 2026
$3.3M
Factors Shaping the Genomic Spectrum of Structural VariantsK99GM155595 · NIGMS · BROAD INSTITUTE, INC. · PI DALIN, SIMONA · 2024 to 2025
$324k
Differential resistance mechanisms to monofunctional vs bifunctional alkylating agents in gliomaF32CA261024 · NCI · BROAD INSTITUTE, INC. · PI DALIN, SIMONA · 2021 to 2023
$208k
NCI NIH HHS F32 CA261024NCI NIH HHS R01 CA188228NCI NIH HHS R01 CA262462NIGMS NIH HHS K99 GM155595NIGMS NIH HHS R35 GM127029
6 · The paper itself

Abstract

Double-strand break (DSB) repair is highly mutagenic compared to normal replication. In budding yeast, repair of an HO endonuclease-induced DSB at

Identifiers

PMID40093125
PMCPMC11908181

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.