Evidence map›Paper›PMID 40093122›Full record

ArticlebioRxiv : the preprint server for biology2025

Sleep Deprivation Alters Hippocampal Dendritic Spines in a Contextual Fear Memory Engram.

Matthew Tennin, Hunter T Matkins, Lindsay Rexrode, Ratna Bollavarapu, Samuel D Asplund, Tanya Pareek, Daniel Kroeger, Harry Pantazopoulos, Barbara Gisabella

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Matthew TenninDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Hunter T MatkinsDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Lindsay RexrodeDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Ratna BollavarapuDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Samuel D AsplundDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Tanya PareekDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Daniel KroegerDepartment of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University.
Harry PantazopoulosDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.
Barbara GisabellaDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA.

Funding

Sex differences in operant cocaine memoriesP20GM144041 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Brigitte Martin · 2023 to 2026
$12.1M
Morphological Correlates of Memory Consolidation During SleepR21MH117460 · NIMH · UNIVERSITY OF MISSISSIPPI MED CTR · PI GISABELLA, BARBARA · 2019 to 2020
$441k
NIGMS NIH HHS P20 GM144041NIMH NIH HHS R21 MH117460
6 · The paper itself

Abstract

Sleep is critically involved in strengthening memories. However, our understanding of the morphological changes underlying this process is still emerging. Recent studies suggest that specific subsets of dendritic spines are strengthened during sleep in specific neurons involved in recent learning. Contextual memories associated with traumatic experiences are involved in post-traumatic stress disorder (PTSD) and represent recent learning that may be strengthened during sleep. We tested the hypothesis that dendritic spines encoding contextual fear memories are selectively strengthened during sleep. Furthermore, we tested how sleep deprivation after initial fear learning impacts dendritic spines following re-exposure to fear conditioning. We used ArcCreER

Identifiers

PMID40093122
PMCPMC11908145

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.