Evidence map›Paper›PMID 40093110›Full record

ArticlebioRxiv : the preprint server for biology2025

Saturation mapping of

Shelby L Hemker, Ashley Marsh, Felicia Hernandez, Elena Glick, Grace Clark, Alyssa Bashir, Krystal Jiang, Jacob O Kitzman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shelby L HemkerDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Ashley MarshAmbry Genetics, Aliso Viejo, CA, 92656, USA.
Felicia HernandezAmbry Genetics, Aliso Viejo, CA, 92656, USA.
Elena GlickDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Grace ClarkDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Alyssa BashirDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Krystal JiangDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Jacob O KitzmanDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-6145-882X

Funding

Expanding the Reach of Massively Parallel Variant Effect ScreensR35GM153286 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jacob Otto Kitzman · 2024 to 2026
$1.5M
NIGMS NIH HHS R35 GM153286
6 · The paper itself

Abstract

Variants of uncertain significance (VUS) limit the actionability of genetic testing. A prominent example is

Identifiers

PMID40093110
PMCPMC11908140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.