Evidence map›Paper›PMID 40093091›Full record

ArticlebioRxiv : the preprint server for biology2025

P4-ATPase control over phosphoinositide membrane asymmetry and neomycin resistance.

Bhawik K Jain, H Diessel Duan, Christina Valentine, Ariana Samiha, Huilin Li, Todd R Graham

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Bhawik K JainDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-1362-6139
H Diessel DuanDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA.
Christina ValentineDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Ariana SamihaDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Huilin LiDepartment of Structural Biology, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0001-8085-8928
Todd R GrahamDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.

Funding

The structure and function of eukaryotic protein glycosylation enzymesR01CA231466 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI Huilin Li · 2018 to 2026
$4.0M
Mechanisms of membrane homeostasis through protein and lipid transportR35GM144123 · NIGMS · VANDERBILT UNIVERSITY · PI TODD R GRAHAM · 2022 to 2026
$2.4M
LSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560k
NCI NIH HHS R01 CA231466NIGMS NIH HHS R35 GM144123NIH HHS S10 OD021630
6 · The paper itself

Abstract

Neomycin, an aminoglycoside antibiotic, has robust antibacterial properties, yet its clinical utility is curtailed by its nephrotoxicity and ototoxicity. The mechanism by which the polycationic neomycin enters specific eukaryotic cell types remains poorly understood. In budding yeast,

Identifiers

PMID40093091
PMCPMC11908233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.