Evidence map›Paper›PMID 40093068›Full record

ArticlebioRxiv : the preprint server for biology2025

Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung.

Shivraj M Yabaji, Suruchi Lata, Anna E Tseng, Prasanna Babu Araveti, Ming Lo, Igor Gavrish, Aoife K O'Connell, Hans P Gertje, Anna C Belkina, Colleen E Thurman and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shivraj M YabajiThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.ORCID 0000-0002-5793-1661
Suruchi LataThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.ORCID 0000-0001-5548-9315
Anna E TsengThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.
Prasanna Babu AravetiThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.ORCID 0000-0002-5441-3826
Ming LoThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.
Igor GavrishThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.ORCID 0000-0001-9810-4091
Aoife K O'ConnellThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.
Hans P GertjeThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.
Anna C BelkinaThe Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118.ORCID 0000-0001-7967-6254
Colleen E ThurmanThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.
Hirofumi KiyokawaCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Darrell KottonCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA; The Pulmonary Center and Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Shumin TanDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA.ORCID 0000-0003-1093-2576
Janice J EndsleyDepartments of Microbiology & Immunology and Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
William R BishaiCenter for Tuberculosis Research School of Medicine, John Hopkins University Baltimore, Maryland.ORCID 0000-0002-8734-4118
Nicholas CrosslandThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.ORCID 0000-0003-3873-9188
Lester KobzikCellecta, Inc., Mountain View, CA.ORCID 0000-0003-4328-937X
Igor KramnikThe National Emerging Infectious Diseases Laboratories (NEIDL), Boston University.ORCID 0000-0001-6511-9246

Funding

Necrosis in pulmonary TB granulomas: dynamics, mechanisms, therapiesR01HL126066 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KRAMNIK, IGOR, NIEDERWEIS, MICHAEL · 2016 to 2025
$5.6M
NHLBI NIH HHS R01 HL126066
6 · The paper itself

Abstract

Pulmonary tuberculosis (PTB) represents 85% of the disease burden caused by

Indexed as

epitheliumimmunityinterferonlungmacrophageTuberculosis

Identifiers

PMID40093068
PMCPMC11908135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.