Evidence map›Paper›PMID 40093059›Full record

ArticlebioRxiv : the preprint server for biology2024

Dynamic fibroblast-immune interactions shape wound healing after brain injury.

Nathan A Ewing-Crystal, Nicholas M Mroz, Anthony A Chang, Eric Dean Merrill, Sofia E Caryotakis, Leon Teo, Amara Larpthaveesarp, Tatsuya Tsukui, Aditya Katewa, Remy Pennington and 14 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Nathan A Ewing-CrystalORCID 0000-0002-2486-1783
Nicholas M Mroz
Anthony A Chang
Eric Dean Merrill
Sofia E Caryotakis
Leon Teo
Amara Larpthaveesarp
Aditya Katewa
Remy Pennington
Gabriel L McKinsey
Sophia Nelson
Agnieszka Ciesielska
Madelene W Dahlgren
Helena Paidassi
Saket Jain
James A Bourne
Jeanne T Paz
Fernando F Gonzalez
Dean Sheppard
Ari B Molofsky

Funding

Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Role of Myeloid And CD4+ T Immune Cells in Post-Traumatic PlasticityR01NS121287 · NINDS · J. DAVID GLADSTONE INSTITUTES · PI Jeanne T Paz · 2022 to 2026
$2.2M
NIGMS NIH HHS T32 GM136547NINDS NIH HHS R01 NS121287
6 · The paper itself

Abstract

Fibroblasts coordinate the response to tissue injury, directing organ regeneration versus scarring. In the central nervous system (CNS), fibroblasts are uncommon cells enriched at tissue borders, and their molecular, cellular, and functional interactions after brain injury are poorly understood. Here we define the fibroblast response to sterile brain damage across time and space. Early pro-fibrotic myofibroblasts infiltrated CNS lesions and were functionally and spatially organized by fibroblast TGF

Identifiers

PMID40093059
PMCPMC11908209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.