Evidence map›Paper›PMID 40093050›Full record

ArticlebioRxiv : the preprint server for biology2025

Biophysical basis for brain folding and misfolding patterns in ferrets and humans.

Gary P T Choi, Chunzi Liu, Sifan Yin, Gabrielle Séjourné, Richard S Smith, Christopher A Walsh, L Mahadevan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Gary P T ChoiDepartment of Mathematics, The Chinese University of Hong Kong, Hong Kong.ORCID 0000-0001-5407-9111
Chunzi LiuSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-3469-3904
Sifan YinSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-0296-3981
Gabrielle SéjournéSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-4633-2700
Richard S SmithDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-1937-6529
Christopher A WalshDepartments of Neurology and Pediatrics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0156-2238
L MahadevanSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-5114-0519

Funding

Cell Identity Determination In Human Brain: Somatic Mutation and Cell LineageR01NS032457 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Alice Eunjung Lee, Christopher A. Walsh · 1995 to 2026
$12.7M
HUMAN EPILEPSY GENETICS--NEURONAL MIGRATION DISORDERSR01NS035129 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WALSH, CHRISTOPHER A. · 1997 to 2023
$9.5M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Role for ion conducting proteins in cortical malformation diseasesR00NS112604 · NINDS · NORTHWESTERN UNIVERSITY · PI SMITH, RICHARD S · 2023 to 2025
$715k
NICHD NIH HHS P50 HD105351NINDS NIH HHS R00 NS112604NINDS NIH HHS R01 NS032457NINDS NIH HHS R01 NS035129
6 · The paper itself

Abstract

A mechanistic understanding of neurodevelopment requires us to follow the multiscale processes that connect molecular genetic processes to macroscopic cerebral cortical formations and thence to neurological function. Using magnetic resonance imaging of the brain of the ferret, a model organism for studying cortical morphogenesis, we create

Identifiers

PMID40093050
PMCPMC11908256

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.