Evidence map›Paper›PMID 40093044›Full record

ArticlebioRxiv : the preprint server for biology2025

Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence.

Sarah Hawes, Bo Liang, Braden Oldham, Breanna T Sullivan, Lupeng Wang, Bin Song, Lisa Chang, Da-Ting Lin, Huaibin Cai

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sarah HawesTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, U.S.A.
Bo LiangIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA.
Braden OldhamTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, U.S.A.
Breanna T SullivanTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, U.S.A.
Lupeng WangTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, U.S.A.
Bin SongTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, U.S.A.
Lisa ChangTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, U.S.A.
Da-Ting LinIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA.
Huaibin CaiTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, U.S.A.

Funding

In vivo imaging of dorsal striatum function in freely behaving miceZIADA000603 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI LIN, DA-TING · 2015 to 2025
$22.3M
Striosomes Constrain Locomotor Vigor in Parkinson's disease and Other Movement DisordersZIAAG000959 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2009 to 2024
$4.0M
Pathobiological Studies of Neurodegenerative DiseasesZ01AG000959 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2004 to 2008
$1.7M
LEADERSHIP AWARD FOR ALZHEIMER'S DISEASE RESEARCHK07AG000959 · NIA · SUNY DOWNSTATE MEDICAL CENTER · PI MIRRA, SUZANNE S · 2000 to 2004
$540k
Intramural NIH HHS Z01 AG000959Intramural NIH HHS ZIA AG000959Intramural NIH HHS ZIA DA000603NIA NIH HHS K07 AG000959
6 · The paper itself

Abstract

Spiny projection neurons (SPNs) in the dorsal striatum play crucial roles in locomotion control and value-based decision-making. SPNs, which include both direct-pathway striatonigral and indirect-pathway striatopallidal neurons, can be further classified into subtypes based on distinct transcriptomic profiles and cell body distribution patterns. However, how these SPN subtypes regulate spontaneous locomotion in the context of environmental valence remains unclear. Using

Indexed as

dorsal striatumenvironmental valencelocomotionpatchy distributionspiny projection neuronsstriatonigral pathway

Identifiers

PMID40093044
PMCPMC11908127

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.