ArticleWorld journal of gastrointestinal oncology2025
Hypercoagulation after neoadjuvant immunochemotherapy as a new prognostic indicator in patients with locally advanced gastric cancer undergoing surgery.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Status quo of hypercoagulation as a prognostic indicator following neoadjuvant immunochemotherapy in locally advanced gastric cancer.World journal of gastrointestinal oncology · 2025Review
- Prognostic value of coagulation markers in locally advanced gastric cancer following neoadjuvant immunochemotherapy.World journal of gastrointestinal oncology · 2025Article
- Prognostic value of post-neoadjuvant immunochemotherapy hypercoagulation in gastric cancer patients undergoing surgery.World journal of gastrointestinal oncology · 2025Article
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Authors and funding
5 authors.
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Abstract
backgroundCoagulation status is closely related to the progression of malignant tumors. In the era of neoadjuvant immunochemotherapy (NICT), the prognostic utility of coagulation indicators in patients with locally advanced gastric cancer (LAGC) undergoing new treatments remains to be determined.
aimTo determine whether hypercoagulation is an effective prognostic indicator in patients with LAGC who underwent radical resection after NICT.
methodsA retrospective analysis of clinical data from 104 patients with LAGC, who underwent radical resection after NICT between 2020 and 2023, was performed. D-dimer and fibrinogen concentrations were measured one week before NICT, and again one week before surgery, to analyze the association between these two indicators and their combined indices [non-hypercoagulation (D-dimer and fibrinogen concentrations within the upper limit of normal)
resultsData collected after NICT revealed that the three-year overall survival (OS) and disease-free survival (DFS) rates the non-hypercoagulation group were significantly better than those in the hypercoagulation group [94.4%
conclusionHypercoagulation after NICT is an effective prognostic indicator in patients with LAGC undergoing radical gastrectomy.
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