Evidence map›Paper›PMID 40092949›Full record

ArticleWorld journal of gastrointestinal oncology2025

To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway.

Zhuo-Cong Bao, Zhao-Dong Liu, Ye Zhang, Hui-Jun Dai, Hui Jia, Fu Ren, Ning Li, Lu Zhao, Yi-Wei Wang, Shang-Yu Lv and 1 more

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Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhuo-Cong BaoGraduate School, Shenyang Medical College, Shenyang 110034, Liaoning Province, China.
Zhao-Dong LiuGraduate School, Shenyang Medical College, Shenyang 110034, Liaoning Province, China.
Ye ZhangGraduate School, Shenyang Medical College, Shenyang 110034, Liaoning Province, China.
Hui-Jun DaiGuangxi Medical University Cancer Hospital, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
Hui JiaSchool of Traditional Chinese Medicine, Shenyang Medical College, Shenyang 110034, Liaoning Province, China.
Fu RenKey Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province, Shenyang Medical College, Shenyang 110034, Liaoning Province, China.
Ning LiKey Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province, Shenyang Medical College, Shenyang 110034, Liaoning Province, China.
Lu ZhaoDepartment of Biochemistry, School of Basic Medicine, Shenyang Medical College, Shenyang 110034, Liaoning Province, China.
Yi-Wei WangKey Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province, Shenyang Medical College, Shenyang 110034, Liaoning Province, China.
Shang-Yu LvBatch 2022, Clinical Medicine, Shenyang Medical College, Shenyang 110034, Liaoning Province, China.
Yan ZhangKey Laboratory of Human Ethnic Specificity and Phenomics of Critical Illness in Liaoning Province, Shenyang Medical College, Shenyang 110034, Liaoning Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver cancer has a high incidence and mortality worldwide, especially in China. Herein, we investigated the therapeutic effect and mechanism of tetrahydrocurcumin against hepatocellular carcinoma (HCC), with a focus on the of phosphoinositide 3-kinases (PI3K)/AKT signaling pathway.

aimTo investigate the effects and mechanism of tetrahydrocurcumin in HCC cell lines HepG2 and Huh7.

methodsUsing Metascape, we analyzed the potential targets of tetrahydrocurcumin in HCC. Molecular docking validation was performed using SYBYL2.0. Cell Counting Kit-8, wound healing, and transwell assays were performed to evaluate the effects of tetrahydrocurcumin on HepG2 and Huh7 cell migration, invasion, and apoptosis. The expression of PI3K/AKT signaling pathway-related proteins was detected by western blotting.

resultsNetwork pharmacology and molecular docking showed that tetrahydrocurcumin has high binding affinity for phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha.

conclusionIn summary, tetrahydrocurcumin suppresses PI3K/AKT signaling, promotes apoptosis, and prevents the migration and invasion of liver cancer cells.

Indexed as

Hepatocellular carcinomaMolecular dockingNetwork pharmacologyPI3K/AKT signaling pathwayTetrahydrocurcumin

Identifiers

PMID40092949
PMCPMC11866248

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