ArticleWorld journal of gastrointestinal oncology2025
Increased risk of colorectal cancer in young males with higher cardiovascular risk: A nationwide population-based cohort study.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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1 citing paper in PubMed, 1 synthesis or guideline pooled it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the link between cardiovascular disease (CVD) and various cancers is well-established, the relationship between CVD risk and colorectal cancer (CRC) remains underexplored.
aimTo elucidate the relationship between CVD risk scores and CRC incidence.
methodsIn this population-based cohort study, participants from the 2009 National Health Checkup were followed-up until 2020. The cardiovascular (CV) risk score was calculated as the sum of risk factors (age, family history of coronary artery disease, hypertension, smoking status, and high-density lipoprotein levels) with high-density lipoprotein (≥ 60 mg/dL) reducing the risk score by one. The primary outcome was incidence of newly diagnosed CRC.
resultsAmong 2526628 individuals, 30329 developed CRC during a mean follow-up of 10.1 years. Categorized by CV risk scores (0, 1, 2, and ≥ 3). CRC risk increased with higher CV risk scores after adjusting for covariates [(hazard ratio = 1.155, 95% confidence interval: 1.107-1.205) in risk score ≥ 3,
conclusionIncreased CV risk scores were significantly associated with higher CRC risk, especially among males, younger populations, and non-statin users. Thus, males with a higher CV risk score, even at a younger age, are recommended to control their risk factors and undergo individualized CRC screening.
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