Evidence map›Paper›PMID 40092920›Full record

ArticleWorld journal of gastrointestinal oncology2025

Hui Xie, Hui Wang, Ru-Hong Li, Yue-Wen Zhang, Xi-Rui Fan, Xiao-Xue He, Ao-Ran Guan

Abstract read
In one paragraph

Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hui XieDepartment of General Surgery, Yan'an Hospital of Kunming City, Kunming 650051, Yunnan Province, China.
Hui WangDepartment of Digestive Internal Medicine, Yan'an Hospital of Kunming City, Kunming 650051, Yunnan Province, China.
Ru-Hong LiDepartment of General Surgery, Yan'an Hospital of Kunming City, Kunming 650051, Yunnan Province, China.
Yue-Wen ZhangDepartment of General Surgery, Yan'an Hospital of Kunming City, Kunming 650051, Yunnan Province, China.
Xi-Rui FanDepartment of Digestive Internal Medicine, Yan'an Hospital of Kunming City, Kunming 650051, Yunnan Province, China.
Xiao-Xue HeDepartment of Digestive Internal Medicine, Yan'an Hospital of Kunming City, Kunming 650051, Yunnan Province, China.
Ao-Ran GuanDepartment of General Surgery, Yan'an Hospital of Kunming City, Kunming 650051, Yunnan Province, China. guanaoran@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer (GC) is a malignant tumor originating from gastric mucosal epithelial cells that has high morbidity and mortality. microRNAs (miR) are important diagnostic markers and therapeutic targets in this disease.

aimTo explore the mechanism of miR-125a-5p in the pathogenesis of GC.

methodsThe expression levels of miR-125a-5p,

resultsThis study revealed that miR-125a-5p was expressed at low levels in GC clinical samples and cells and that miR-125a-5p overexpression inhibited the proliferation, migration, invasiveness and EMT of GC cells. Mechanistically, miR-125a-5p can reduce GC cell proliferation, promote E-cadherin expression, inhibit N-cadherin and vimentin expression, and reduce the EMT of GC cells, thus constraining GC cells to a certain extent. Moreover,

conclusionOur study revealed that

Indexed as

DNA methyltransferase 1Gastric cancerMethylationmicroRNA-125a-5pSERPINE1

Identifiers

PMID40092920
PMCPMC11866249

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.