Evidence map›Paper›PMID 40092911›Full record

ArticleTechnical innovations & patient support in radiation oncology2025

Treatment efficiency and quality improvement via double imaging modality (DIM) versus single imaging modality (SIM) image-guided radiotherapy for prostate cancer.

Milad Mirzaei, Suki Gill, Mahsheed Sabet, Martin A Ebert, Pejman Rowshanfarzad, Jake Kendrick, Angela Jacques, Clare Herbert, Jeremy Croker, Sean Bydder and 7 more

Abstract read
In one paragraph

Article in Technical innovations & patient support in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Milad MirzaeiDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Suki GillDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Mahsheed SabetDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Martin A EbertDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Pejman RowshanfarzadSchool of Physics, Mathematics and Computing, University of Western Australia, Crawley, WA, Australia.
Jake KendrickSchool of Physics, Mathematics and Computing, University of Western Australia, Crawley, WA, Australia.
Angela JacquesDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Clare HerbertDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Jeremy CrokerDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Sean BydderDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Joshua DassDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Edward BaileyDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Rohen WhiteDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Catherine MoffatDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Colin TangDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Adriano PolpoSchool of Physics, Mathematics and Computing, University of Western Australia, Crawley, WA, Australia.
Nicholas BucknellDepartment of Radiation Oncology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Daily image-guided radiotherapy (IGRT) for prostate cancer reduces treatment-related toxicity. However, positional and anatomical variations can result in patient re-setup, increased treatment time, and additional imaging dose. A simple technique of two distinct imaging modalities was investigated: initially, an anteroposterior kilovoltage (AP-kV) planar image was acquired, followed by cone beam computed tomography (CBCT). To determine whether this dual imaging modality (DIM) can reduce repeat CBCTs with an AP-kV screening image compared to CBCT alone, Methods: Patients were enrolled sequentially before and after the new departmental protocol for IGRT. Initially, all patients had a CBCT prior to treatment (SIM group) as usual. For the DIM group, AP-kV imaging was added to the first three fractions, and subsequent AP-kV imaging (on demand) for patients unable to maintain adequate bladder and bowel compliance. Sixty intact prostate or post-prostatectomy patients were included: 30 before the change in protocol (SIM group) and 30 after (DIM group). Bladder volume, rectal filling, and positioning errors were evaluated. Results: In the SIM group, 30 patients underwent a total of 1116 CBCTs. In the DIM group, 30 patients had 156 AP-kV images and 1077 CBCTs. In the SIM group, 166 were repeat CBCTs with a median of 4 repeat CBCTs per patient. In DIM group, 132 were repeat CBCTs with a median of 3 repeat CBCTs per patient. We found a significant difference in incidence of repeat CBCTs due to suboptimal bladder filling (p = 0.028) and rectal gas (p = 0.045), indicating the number of repeat CBCTs was significantly lower in patients imaged with DIM. Conclusion: The DIM technique was found to be superior to the SIM technique, as it allowed the desired bladder volume, rectal condition, and patient positioning to be achieved prior to CBCT, reducing the need for repeat CBCTs.

Indexed as

Anteroposterior kilovoltage imaging (AP-kV)BladderCBCTIGRTProstateRectal gas

Identifiers

PMID40092911
PMCPMC11907479

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.