Evidence map›Paper›PMID 40092635›Full record

ArticleCrohn's & colitis 3602025

Multimodal Lifestyle Intervention Improves Fatigue in Quiescent Inflammatory Bowel Disease: A Controlled Study.

Roberta Loveikyte, Lola J M Koppelman, Mirjam J H Blijleven, Nathalie Wilmsen, Mar D M Rodríguez-Girondo, Sjaak Bloem, Philip W Voorneveld, Andrea E van der Meulen-de Jong, Sander van der Marel, P W Jeroen Maljaars

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Crohn's & colitis 360, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roberta LoveikyteDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.ORCID https://orcid.org/0000-0002-3183-9007
Lola J M KoppelmanDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.
Mirjam J H BlijlevenVoeding Leeft non-profit foundation, Amsterdam, the Netherlands.
Nathalie WilmsenVoeding Leeft non-profit foundation, Amsterdam, the Netherlands.
Mar D M Rodríguez-GirondoDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
Sjaak BloemCenter for Marketing & Supply Chain Management, Nyenrode Business University, Breukelen, the Netherlands.
Philip W VoorneveldDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.
Andrea E van der Meulen-de JongDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.
Sander van der MarelDepartment of Gastroenterology and Hepatology, Haaglanden Medical Center, The Hague, the Netherlands.
P W Jeroen MaljaarsDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lifestyle factors are significant contributors to fatigue, affecting ~45% of patients with inflammatory bowel disease (IBD). Hence, we evaluated the effect of a multimodal lifestyle intervention on fatigue in patients with IBD. Methods: Patients with quiescent IBD were enrolled in this multicenter, non-randomized, controlled interventional study. The intervention group followed a 12-month lifestyle program, which included digital group meetings with a nutritionist and a lifestyle coach focusing on nutrition, exercise, sleep, and relaxation. The program also encouraged patients to exercise more self-control over personal health. The control group received standard clinical care. Clinical data and patient-reported outcomes were collected. Fatigue was measured with the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F); any increase in FACIT-F was considered a positive response to the intervention. Inverse probability treatment weighting was used to correct confounding by indication. Results: Thirty-six patients in the intervention group and 32 in the control group were compared. More patients in the intervention group (82.1%) than in the control group (54.2%) experienced improvement in fatigue, Conclusions: Multimodal lifestyle intervention improves fatigue in patients with IBD. Acceptance appears essential for fatigue improvement; instruments evaluating acceptance could help to personalize treatment and maximize its effectiveness.

Indexed as

fatigueinflammatory bowel diseaselifestyle interventionnutrition

Identifiers

PMID40092635
PMCPMC11906969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.