Evidence map›Paper›PMID 40092629›Full record

ArticleFrontiers in cell and developmental biology2025

Transcriptomic insights into developmental arrest in fluorescent labeling transgenic Asian elephant (

Peachanika Pankammoon, Yubo Qing, Heng Zhao, Deling Jiao, Honghui Li, Fengchong Wang, Thanapa Wiriyahdamrong, Jianxiong Guo, Wengui Li, Phongsakorn Chuammitri and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Peachanika PankammoonFaculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
Yubo QingFaculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
Heng ZhaoScience and Technology Department of Yunnan Province, Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Kunming, China.
Deling JiaoScience and Technology Department of Yunnan Province, Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Kunming, China.
Honghui LiScience and Technology Department of Yunnan Province, Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Kunming, China.
Fengchong WangScience and Technology Department of Yunnan Province, Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Kunming, China.
Thanapa WiriyahdamrongScience and Technology Department of Yunnan Province, Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Kunming, China.
Jianxiong GuoScience and Technology Department of Yunnan Province, Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Kunming, China.
Wengui LiCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.
Phongsakorn ChuammitriFaculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
Chatchote ThitaramFaculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
Hongjiang WeiScience and Technology Department of Yunnan Province, Yunnan Province Key Laboratory for Porcine Gene Editing and Xenotransplantation, Kunming, China.
Anucha SathanowongsFaculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Asian elephants ( Methods: This study conducted low-input RNA sequencing analyses on transgenic Asian elephant-pig (AE-P) inter-order cloned embryos expressing enhanced green fluorescent protein (EGFP) at the 2- and 4-cell stages. Differential gene expressions, pathway enrichment, and hub gene analyses were performed to identify the molecular mechanisms and core genes influencing normal and arrest development. Results and Discussion: Approximately 25% of clean reads successfully aligned with the Asian elephant genome. The transcriptomic analysis revealed that inter-order cloned embryos with earlier cleavage at the 2- and 4-cell stages exhibited signs of residual transcriptomic memory and incomplete epigenetic reprogramming, while arrested embryos showed indications of nucleocytoplasmic incompatibility and nDNA-mtDNA mismatch. Hub gene analyses indicated core genes such as

Indexed as

Asian elephant (Elephas maximus)embryonic arrestinterspecies cloninginterspecies somatic cell nuclear transfer technique (iSCNT)RNA sequencing (RNAseq)transcriptomic analysis

Identifiers

PMID40092629
PMCPMC11907086

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.